rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mosaicism in Human Skin
    sub title: Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia
  name:
    name part: Happle, Rudolf.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIII, 229 p. 232 illus., 208 illus. in color. online resource.
  abstract: Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.
  table of contents: PATTERNS AND MECHANISMS: Mosaicism as a Biological Concept: -- History -- Mosaicism in Plants, Animals, Humans -- Mosaicism Versus Chimerism -- The Mechanisms of Mosaicism -- Genomic Mosaicism of Autosomes -- Epigenetic Mosaicism of autosomes -- Genomic Mosaicism of X Chromosomes -- Epigenetic Mosaicism of X Chromosomes -- The patterns of Mosaicism -- Lines of Blaschko -- Checkerboard Pattern -- Phylloid Pattern -- Patchy Pattern Without Midline Separation -- Lateralization -- Other Patterns, so far Unclassifiable -- MOSAIC SKIN DISORDERS: Nevi -- Melanocytic Nevi -- Other Forms of Pigmentary Mosaicism -- Epidermal Nevi -- Vascular Nevi -- Connective Tissue Nevi -- Nevoid Skin Disorders -- Lyonization (Functional X-Chromosome Mosaicism) in X-Linked Skin Disorders -- Autosomal Non-Nevi -- Neoplastic Skin Lesions -- Benign Tumors -- Malignant Tumors -- CONCLUSION.
  note: by Rudolf Happle.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Dermatology
  subject:
    topic: Neurology
  subject:
    topic: Ophthalmology
  subject:
    topic: Pediatrics
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Dermatology
  subject:
    topic: Pediatrics
  subject:
    topic: Human Genetics
  subject:
    topic: Neurology
  subject:
    topic: Ophthalmology
  classification: RL1-803
  classification: 616.5
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783642387654
  identifier: http://dx.doi.org/10.1007/978-3-642-38765-4
  record info:
    record creation date: 131125
    record change date: 20131127032334.0
    record identifier: 978-3-642-38765-4