rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Voltage Gated Sodium Channels
  name:
    name part: Ruben, Peter C.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 295 p. 58 illus., 36 illus. in color. online resource.
  abstract: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
  table of contents: Overview: biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels -- Slow inactivation of Na+ channels -- Regulation/modulation of sensory neuron sodium channels -- Ubiquitylation of voltage-gated sodium channels -- Probing gating mechanisms of sodium channel using pore blockers -- Animal toxins influence voltage-gated sodium channel function -- Voltage-sensor trapping toxins: Iso form-specific ligands for sodium channels -- Pharmacological insights and quirks of bacterial sodium channels -- The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels -- The role of late INa in development of cardiac arrhythmias -- Proton modulation of cardiac INa: A potential arrhythmogenic trigger -- Altered sodium channel gating as molecular basis for pain: Contribution of activation, inactivation and resurgent currents. .
  note: edited by Peter C. Ruben.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Pharmacology
  subject:
    topic: Cardiology
  subject:
    topic: Proteins
  subject:
    topic: Cell membranes
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Neurosciences
  subject:
    topic: Cardiology
  subject:
    topic: Membrane Biology
  subject:
    topic: Protein Structure
  classification: RM1-950
  classification: 615
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Handbook of Experimental Pharmacology, 221
  identifier: 9783642415883
  identifier: http://dx.doi.org/10.1007/978-3-642-41588-3
  record info:
    record creation date: 140415
    record change date: 20151204183820.0
    record identifier: 978-3-642-41588-3