rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Modelling Proteasome Dynamics in a Bayesian Framework
  name:
    name part: Stübler, Sabine.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 96 p. 30 illus., 10 illus. in color. online resource.
  abstract: Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition. Contents Structure and Function of the Proteasome Approaches to Model Proteasome Dynamics Comparison of the Dynamics of Proteasome Subtypes Inhibitor Influence on the Catalytic Subunits Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model Target Groups Lecturers and students of systems biology, immunology and cell biology Practitioners from the fields of systems biology, immunology and cell biology About the Author Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.
  table of contents: Structure and Function of the Proteasome -- Approaches to Model Proteasome Dynamics -- Comparison of the Dynamics of Proteasome Subtypes -- Inhibitor Influence on the Catalytic Subunits -- Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model . .
  note: by Sabine Stübler.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Bioinformatics
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Immunology
  subject:
    topic: Bioinformatics
  subject:
    topic: Cell Biology
  classification: QR180-189.5
  classification: 616.079
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: BestMasters
  identifier: 9783658201678
  identifier: http://dx.doi.org/10.1007/978-3-658-20167-8
  record info:
    record creation date: 171130
    record change date: 20171130123827.0
    record identifier: 978-3-658-20167-8