rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Predictive Methods in Percutaneous Absorption
  name:
    name part: Moss, Gary P.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Gullick, Darren R.
    role:
      role term: author.
  name:
    name part: Wilkinson, Simon C.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 199 p. 16 illus., 8 illus. in color. online resource.
  abstract: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
  table of contents: Skin Structure and Physiology -- Methods for the Measurement of Percutaneous Absorption -- Mathematical Treatments and Early Models of Skin Permeability -- “Building error upon error”: The New Breadth of Research in the Field -- Algorithms for Estimating Permeability Across Artificial Membranes -- Other Approaches to Modelling Percutaneous Absorption -- “Squiggly lines and random dots – you can fit anything with a non-linear model” -- Finite-dose models of transient exposures and volatile formulation components -- “The Devil Is in the Detail …” -- Conclusions and Recommendations for Model Development and Use.
  note: by Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson.
  subject:
    topic: Medicine
  subject:
    topic: Human physiology
  subject:
    topic: Pharmacology
  subject:
    topic: Dermatology
  subject:
    topic: Biomathematics
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Human Physiology
  subject:
    topic: Dermatology
  subject:
    topic: Physiological, Cellular and Medical Topics
  classification: RM1-950
  classification: 615
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783662473719
  identifier: http://dx.doi.org/10.1007/978-3-662-47371-9
  record info:
    record creation date: 150701
    record change date: 20151204191117.0
    record identifier: 978-3-662-47371-9