rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies
  name:
    name part: Bi, Yunchen.
    role:
      role term: creator
    role:
      role term: author.
    role:
      role term: aut
    role:
      role term: http://id.loc.gov/vocabulary/relators/aut
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2018
    edition: 1st ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 79 p. 41 illus. online resource.
  abstract: This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.
  table of contents: Introduction -- Review -- Nanodisc assembly and the study on the interaction between the lipid and ion -- Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation -- The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin -- Summary and prospect of this dissertation.
  note: by Yunchen Bi.
  subject:
    topic: Biomedical engineering
  subject:
    topic: Biophysics
  subject:
    topic: Biological physics
  subject:
    topic: Cell membranes
  subject:
    topic: Immunology
  subject:
    topic: Atomic structure
  subject:
    topic: Molecular structure
  subject:
    topic: Biomedical Engineering and Bioengineering
  subject:
    topic: Biological and Medical Physics, Biophysics
  subject:
    topic: Membrane Biology
  subject:
    topic: Immunology
  subject:
    topic: Atomic/Molecular Structure and Spectra
  classification: R856-857
  classification: HC79.E5
  classification: GE220
  classification: 610.28
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses, Recognizing Outstanding Ph.D. Research
  identifier: 9783662546185
  identifier: https://doi.org/10.1007/978-3-662-54618-5
  record info:
    record creation date: 170620
    record change date: 20191023141846.0
    record identifier: 978-3-662-54618-5