rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Store-operated Ca2+ entry (SOCE) pathways
    sub title: Emerging signaling concepts in human (patho)physiology
  name:
    name part: Groschner, Klaus.
    role:
      role term: editor.
  name:
    name part: Graier, Wolfgang F.
    role:
      role term: editor.
  name:
    name part: Romanin, Christoph.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: au
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXII, 482 p. online resource.
  abstract: Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.
  table of contents: Preface (C. Romanin, W. F. Graier, K. Groschner) -- SECTION 1: SOCE – Fundamental mechanistic concepts -- Introduction (J. W. Putney) -- 1.1 The STIM-Orai pathway -- Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura) -- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan) -- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin) -- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem) -- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu) -- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca) -- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: Endogenous messengers and mediators (V. M. Bolotina) -- SECTION 2: SOCE – Crosstalk between organelle and cellular compartments -- Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh) -- 2.1 New aspects of the contribut ion of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. Tepikin) -- 2.2 New aspects of the contribution of ER to SOCE regulation. The contribution of SERCA to the regulation of SOCE (J. García-Sancho, M. T. Alonso) -- 2.3 New aspects of the contribution of ER to SOCE regulation. TRPC proteins as a link between plasma membrane ion transport and intracellular Ca2+ stores (A. Bavencoffe, M. X. Zhu) -- 2.4 The role of mitochondria in the activation/maintenance of SOCE. Store-operated Ca2+ entry and mitochondria (A. Spät, G. Szanda) -- 2.5 The role of mitochondria in the activation/maintenance of SOCE. Local regulation of plasma membrane…
  note: edited by Klaus Groschner, Wolfgang F. Graier, Christoph Romanin.
  subject:
    topic: Medicine
  subject:
    topic: Human physiology
  subject:
    topic: Molecular biology
  subject:
    topic: Cardiology
  subject:
    topic: Cell biology
  subject:
    topic: Biophysics
  subject:
    topic: Biomedicine
  subject:
    topic: Molecular Medicine
  subject:
    topic: Cell Biology
  subject:
    topic: Human Physiology
  subject:
    topic: Physics of the Cell
  subject:
    topic: Cardiology
  classification: QH506
  classification: 611.01816
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783709109625
  identifier: http://dx.doi.org/10.1007/978-3-7091-0962-5
  record info:
    record creation date: 120420
    record change date: 20151125151041.0
    record identifier: 978-3-7091-0962-5