rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Aromatase Inhibitors
  name:
    name part: Furr, Barrington J.A.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: sz
    date issued: 2006
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: IX, 182 p. 30 illus. online resource.
  abstract: Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
  table of contents: Background and development of aromatase inhibitors -- Aromatase inhibitors and models for breast cancer -- Clinical pharmacology of aromatase inhibitors -- Clinical studies with exemestane -- Clinical studies with letrozole -- Clinical studies with anastrozole -- The third-generation aromatase inhibitors: a clinical overview -- Lessons from the ArKO mouse -- Possible additional therapeutic uses of aromatase inhibitors.
  note: edited by Barrington J.A. Furr.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Pharmacology
  subject:
    topic: Internal medicine
  subject:
    topic: Oncology
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Internal Medicine
  subject:
    topic: Oncology
  subject:
    topic: Cell Biology
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Milestones in Drug Therapy MDT
  identifier: 9783764374181
  identifier: http://dx.doi.org/10.1007/3-7643-7418-7
  record info:
    record creation date: 100301
    record change date: 20151031031034.0
    record identifier: 978-3-7643-7418-1