rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Complement and Kidney Disease
  name:
    name part: Zipfel, Peter F.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: sz
    date issued: 2006
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 236 p. online resource.
  abstract: It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
  table of contents: The complement system in renal diseases -- Complement in renal transplantation -- C1q and the glomerulonephritides: therapeutic approaches for the treatment of complement-mediated kidney diseases -- Complement deficient mice as model systems for kidney diseases -- Non-Shiga toxin-associated hemolytic uremic syndrome -- Role of complement and Factor H in hemolytic uremic syndrome -- Genetic testing in atypical HUS and the role of membrane cofactor protein (MCP; CD46) and Factor I -- Towards a new classification of hemolytic uremic syndrome -- Therapeutic strategies for atypical and recurrent hemolytic uremic syndromes (HUS) -- Complement defects in children which result in kidney diseases: diagnosis and therapy -- The role of complement in membranoproliferative glomerulonephritis -- The experience of a patient advocacy group.
  note: edited by Peter F. Zipfel.
  subject:
    topic: Medicine
  subject:
    topic: Human physiology
  subject:
    topic: Immunology
  subject:
    topic: Medical microbiology
  subject:
    topic: Internal medicine
  subject:
    topic: Nephrology
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Immunology
  subject:
    topic: Cell Biology
  subject:
    topic: Nephrology
  subject:
    topic: Human Physiology
  subject:
    topic: Internal Medicine
  subject:
    topic: Medical Microbiology
  classification: QR180-189.5
  classification: 616.079
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Progress in Inflammation Research
  identifier: 9783764374280
  identifier: http://dx.doi.org/10.1007/3-7643-7428-4
  record info:
    record creation date: 100301
    record change date: 20151030101437.0
    record identifier: 978-3-7643-7428-0