rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
  name:
    name part: Inuki, Shinsuke.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ja
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 106 p. online resource.
  abstract: The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.
  table of contents: Chapter 1. Total Synthesis of Pachastrissamine (Jaspine B) -- Chapter 2. Total Synthesis of Lysergic Acid, Lysergol, and Isolysergol -- Chapter 3. Conclusions.
  note: by Shinsuke Inuki.
  subject:
    topic: Chemistry
  subject:
    topic: Bioorganic chemistry
  subject:
    topic: Catalysis
  subject:
    topic: Chemistry
  subject:
    topic: Bioorganic Chemistry
  subject:
    topic: Catalysis
  classification: QD241-441
  classification: 547
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses
  identifier: 9784431540434
  identifier: http://dx.doi.org/10.1007/978-4-431-54043-4
  record info:
    record creation date: 111122
    record change date: 20130726172901.0
    record identifier: 978-4-431-54043-4