rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome
  name:
    name part: Kaneko, Kazunari.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ja
    date issued: 2016
    edition: 1st ed. 2016.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 240 p. 21 illus., 16 illus. in color. online resource.
  abstract: This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN). As the word “idiopathic” indicates, the pathogenesis of INS remains unclear. Historically, T-cell dysfunction has been thought to play an important part in the pathogenesis of MCNS, while circulating vascular permeabilities have been believed to induce proteinuria in FSGS. The book further describes recent advances in molecular biology, which have allowed us to speculate on the interactions between visceral glomerular epithelial cells (podocytes) and the relative significance of several molecules in the pathogenesis of INS, such as reactive oxygen species, nuclear factor-kappa B, CD80, angiopoietin-like 4, cardiotrophin-like cytokine-1, and M-type phospholipase A2 receptor. The normally rapid pace of scientific progress occasionally devolves into a state of chaos, and the pathogenetic research on INS is one such case. This volume will help researchers and scientists to collaborate, share resources, and expedite the design of protocols to evaluate the putative factors.
  table of contents: Part 1. Introduction -- 1. History of Research on Pathogenesis of Idiopathic Nephrotic Syndrome -- Part 2. Minimal-change nephrotic syndrome (MCNS) -- 2. Hemopexin in Minimal Change Nephrotic Syndrome -- 3. Angiopoietin-like-4 (Angptl4) in MCNS -- 4. Co-stimulatory molecule CD80 (B7.1) in MCNS -- 5. Energy and Mammalian target of rapamycin complex 1 (mTORC1) in minimal change nephrotic syndrome -- 6. The role of c-mip in the pathogenesis of Minimal Change Nephrotic Syndrome -- 7. REGULATORY T-CELLS AND OXIDATIVE STRESS IN MINIMAL CHANGE NEPHROPATHY -- 8. CYTOKINES AS ACTIVE FACTORS IN MINIMAL CHANGE NEPHROTIC SYNDROME -- Part 3. Focal segmental glomerulosclerosis (FSGS) -- 9. Soluble urokinase-type plasminogen activator receptor (suPAR) in Focal Segmental Glomerulosclerosis -- 10. CYTOKINES AS ACTIVE FACTORS IN FOCAL SEGMENTAL GLOMERULOSCLEROSIS -- Part 4. Idiopathic Membranous Nephropathy (IMN) -- 11. M-Type Phospholipase A2 Receptor (PLA2R) and Thrombospondin Type-1 Domain-Containing 7A (THSD7A) in Membranous Nephropathy -- 12. Cationic Bovine Serum Albumin as Cause of Membranous Nephropathy: From Mice to Men -- Part 5. Treatment in Idiopathic Nephrotic Syndrome -- 13. Podocytes as a direct target of drugs used in Idiopathic Nephrotic Syndrome.
  note: edited by Kazunari Kaneko.
  subject:
    topic: Medicine
  subject:
    topic: Molecular biology
  subject:
    topic: Nephrology
  subject:
    topic: Urology
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Nephrology
  subject:
    topic: Urology
  subject:
    topic: Molecular Medicine
  classification: RC902-918
  classification: 616.61
  related item:
    title info:
      title: Springer eBooks
  identifier: 9784431552703
  identifier: http://dx.doi.org/10.1007/978-4-431-55270-3
  record info:
    record creation date: 151026
    record change date: 20151028041614.0
    record identifier: 978-4-431-55270-3