rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia
  name:
    name part: Kizaki, Masahiro.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ja
    date issued: 2016
    edition: 1st ed. 2016.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 193 p. 26 illus., 20 illus. in color. online resource.
  abstract: Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, diagnosis, and prognosis for understanding and facilitating daily practice in the management of patients with CML. Understanding of the pathogenesis and therapy of hematological malignancies such as CML has grown significantly in recent years. This development owe much to the progress in molecular biology and now makes a major contribution to diagnosis and to treatment that pharmacologically targets the molecular events of CML. Molecular targeting therapy with newly developed agents such as small molecules and antibodies for hematological malignancies are being discovered after years of research. Some of these, including tyrosine kinase inhibitors such as imatinib, nilotinib, and dasatinib, lead to increased survival rates and improved therapies. With the opinion leaders of basic and clinical research in the field as authors, this book reviews recent advances in the biology of CML.
  table of contents: 1. Identification and Biology of CML Stem Cells.- 2. Molecular Mechanisms of CML Stem Cell Maintenance -- 3. Roles for Signaling Molecules in the Growth and Survival of CML Cells.- 4. Goal of CML Treatment in the Tyrosine Kinase Inhibitor Era.- 5. Biomarkers for Determining the Prognosis of CML -- 6. Updated European Leukemia Net Recommendations for the Management of CML -- 7. Optimal Monitoring of CML Treatment: Molecular and Mutation Analysis -- 8. Recommendations for Management of CML in the Era of Second-Generation TKIs -- 9. Role of New TKIs and Combinations with Interferon-α for the Treatment of CML -- 10. Safety Profiles of First-Line TKIs and Managing Adverse Effects -- 11. Molecular Mechanism of TKI Resistance and Potential Approaches to Overcome Resistance -- 12. Discontinuation of Therapy and Treatment-Free Remission in CML.
  note: edited by Masahiro Kizaki.
  subject:
    topic: Medicine
  subject:
    topic: Hematology
  subject:
    topic: Oncology
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Hematology
  subject:
    topic: Oncology
  classification: RB45
  classification: 616.15
  related item:
    title info:
      title: Springer eBooks
  identifier: 9784431557142
  identifier: http://dx.doi.org/10.1007/978-4-431-55714-2
  record info:
    record creation date: 151105
    record change date: 20160901111147.0
    record identifier: 978-4-431-55714-2