rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Immunopharmacogenomics
  name:
    name part: Nakamura, Yusuke.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ja
    date issued: 2015
    edition: 1st ed. 2015.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: IX, 162 p. 30 illus., 29 illus. in color. online resource.
  abstract: This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge. .
  table of contents: PART I TECHNOLOGIES -- 1 Deep Sequencing of T-Cell and B-Cell Receptors with Next-Generation DNA Sequencers -- 2 A TCR Sequence Data Analysis Pipeline: Tcrip -- PART II APPLICATIONS -- 3 Prediction of Drug-Induced Adverse Reactions: Skin Hypersensitivity and Liver Toxicity -- 4 Selection and Monitoring of Patients for Immunotherapy (Peptide Vaccines) -- 5 Patient Selection and Monitoring for Immunotherapies: Challenges for Immune Checkpoint Antibody and Cell Therapies -- 6 Better Understanding of Rejection After Organ Transplantation -- 7 Better Understanding of Severe Immunological Reactions: Autoimmune Diseases -- 8 Better Understanding of Severe Immunological Reactions: Food Allergy -- 9 Immune Microenvironment to Predict Response of Cancer Chemotherapy and Radiotherapy -- PART III CHALLENGES AND FUTURE -- 10 Challenges and Future Directions of Immunopharmacogenomics. .
  note: edited by Yusuke Nakamura.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Human genetics
  subject:
    topic: Molecular biology
  subject:
    topic: Pharmacology
  subject:
    topic: Biomedicine
  subject:
    topic: Human Genetics
  subject:
    topic: Cancer Research
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Molecular Medicine
  classification: RB155-155.8
  classification: QH431
  classification: 611.01816
  classification: 599.935
  related item:
    title info:
      title: Springer eBooks
  identifier: 9784431557265
  identifier: http://dx.doi.org/10.1007/978-4-431-55726-5
  record info:
    record creation date: 150824
    record change date: 20160309164443.0
    record identifier: 978-4-431-55726-5