rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Perspectives in inflammation biology
  name:
    name part: Banerjee, Ena Ray.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ii
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 148 p. 66 illus., 15 illus. in color. online resource.
  abstract: “Perspectives in Inflammation Biology” outlines detailed studies using preclinical murine models in Inflammation. The book is meant for academicians, industry persons, research scholars and students alike. The detailed perspective for a beginner and the exhaustive methodologies and analyses outlined, for the veteran researcher, makes this book a unique link between someone who is thinking of embarking on a study of inflammation and one who is delving deep into this area of specialization. The book deals with asthma and allergy as specific disease areas of inflammation of the lung, aseptic peritonitis as a disease of systemic inflammation and details how each role player in its pathophysiology has a unique niche of activity. Data acquisition, sequentiality and analyses in context demonstrate how each role player is validated systematically to become a target for drug discovery. Methods and models used in the course of my work and their relevance will demonstrate to the researcher how a study can be developed from an idea. Further into a researcher’s ongoing work, this book is meant to stimulate new questions and pave ways for better dissection of a phenomenon. The highlights of this book are the detailed tables tabulating sub species of immune cells, their inflammatory recruitment indices, their translation into tissue-to-tissue traffic of the inflammatory stimulus and the delicate interplay of resident structural cells, cells recruited from circulation, their feedback poiesis in bone marrow, their instruction in the lymphoid organs and tissues as well as the non-cellular mediators synthesized from corresponding genetic instruction. The book shall definitely help students and researchers how a disease can be simplified from its complex ramifications and network of implications and put back into perspective and the whole thing falls into place without an intimate understanding of the mechanism and the compelling circumstances that causes a disease, a drug hunter canno…
  table of contents: Chapter 1. Pulmonary and Systemic inflammation -- Chapter 2. Preclinical models of acute and chronic models of lung inflammation -- Chapter 3. Studying the roles of some key molecules in acute allergic asthma -- Research area 1- Enantiomers of albuterol, the OTC drug of choice for acute asthma management -- Research area 2. Studies on prophylactic and therapeutic strategies to combat some local and systemic inflammatory pathologies -- Sub-chapter I. Role of integrin α4 (VLA- Very Late Antigen 4) and integrin β2 (CD18) in a pulmonary inflammatory and a systemic disease model using genetic knockout mice -- Sub-chapter 2. Role of E-, L-, and P-selectins in the onset, maintenance and development of acute allergic asthma -- Sub-Chapter 3. Role of gp91phox subunit of NADPH oxidase and MMP-12 in a acute inflammatory and an acute degenerative pulmonary disease model using genetic knockout mice -- Chapter 4. Role of integrins α4 and β2 onset and development of chronic allergic asthma in mice -- Chapter 5 Role of integrin α4 (VLA- Very Late Antigen 4) in lymphopoiesis by short and long term transplantation studies in genetic knockout model of mice -- Chapter 6. Studying the roles of some critical molecules in systemic inflammation. .
  note: by Ena Ray Banerjee.
  subject:
    topic: Life sciences
  subject:
    topic: Cytokines
  subject:
    topic: Growth factors
  subject:
    topic: Cell biology
  subject:
    topic: Stem cells
  subject:
    topic: Microbial ecology
  subject:
    topic: Animal models in research
  subject:
    topic: Biology
    topic: Technique
  subject:
    topic: Life Sciences
  subject:
    topic: Cell Biology
  subject:
    topic: Stem Cells
  subject:
    topic: Microbial Ecology
  subject:
    topic: Cytokines and Growth Factors
  subject:
    topic: Biological Techniques
  subject:
    topic: Animal Models
  classification: QH573-671
  classification: 571.6
  related item:
    title info:
      title: Springer eBooks
  identifier: 9788132215783
  identifier: http://dx.doi.org/10.1007/978-81-322-1578-3
  record info:
    record creation date: 131015
    record change date: 20151204162858.0
    record identifier: 978-81-322-1578-3