rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Endotoxins: Structure, Function and Recognition
  name:
    name part: Wang, Xiaoyuan.
    role:
      role term: editor.
  name:
    name part: Quinn, Peter J.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVII, 415 p. online resource.
  abstract: Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.
  table of contents: I Structure and Properties of Endotoxins -- Endotoxins: Lipopolysaccharides of Gram-Negative Bacteria -- Purification and Characterization of Lipopolysaccharides -- Endotoxins: Relationship Between Structure, Function, and Activity -- The Diversity of the Core Oligosaccharide in Lipopolysaccharides -- Salmonella-Regulated Lipopolysaccharide Modifications -- The Variation of O Antigens in Gram-Negative Bacteria -- Regulators of TLR4 Signaling by Endotoxins -- Membrane Partitioning: Is Location Everything When It Comes to Endotoxin Recognition? -- Infection, Treatment and Immunity -- Endotoxin Detection – from Limulus Amebocyte Lysate to Recombinant Factor C -- The Role of Endotoxin in Infection: Helicobacter pylori and Campylobacter jejuni -- The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infection -- Development of Small-Molecule Endotoxin Sequestering Agents -- Development of an Anti-Endotoxin Vaccine for Sepsis -- Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants -- Targeting Endotoxin in the Treatment of Sepsis -- Lipopolysaccharides in Rhizobium-Legume Symbioses -- Lipopolysaccharides and Plant Innate Immunity.
  note: edited by Xiaoyuan Wang, Peter J. Quinn.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Medical microbiology
  subject:
    topic: Pharmacology
  subject:
    topic: Infectious diseases
  subject:
    topic: Biomedicine
  subject:
    topic: Medical Microbiology
  subject:
    topic: Infectious Diseases
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Immunology
  classification: QR46
  classification: 616.9041
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Subcellular Biochemistry, 53
  identifier: 9789048190782
  identifier: http://dx.doi.org/10.1007/978-90-481-9078-2
  record info:
    record creation date: 100702
    record change date: 20151204163013.0
    record identifier: 978-90-481-9078-2