rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Antibody Expression and Production
  name:
    name part: Al-Rubeai, Mohamed.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 346 p. online resource.
  abstract: Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.
  table of contents: 1 Expression of antibody in mammalian cells, Thomas Jostock -- 2 Bioreactor systems for producing antibody from mammalian cells, Darrin Kuystermans and Mohamed Al-Rubeai -- 3 Production of antibody in insect cells, Hideki Yamaji -- 4 Production of monoclonal antibodies in glycoengineered Pichia pastoris, Dongxing Zhu, Thomas Linden and Thomas Potgieter -- 5 Production of antibodies in Hansenula polymorpha, Georg Melmer, Stephan Hellwig, Grit Hehmann and Ulrike Dahlems -- 6 Expression of antibody in transgenic avians, Yoshinori Kawabe and Masamichi Kamihira -- 7 Production of antibodies in plants, Alejandro Sarrion-Perdigones, Paloma Juarez, Antonio Granell and Diego Orzaez -- 8 Production of antibody fab fragments in Escherichia coli, Hiroshi Tachibana and Masataka Takekoshi -- 9 Intrabody expression in mammalian cells, Silvia Biocca -- 10 Engineering of antibodies for cancer therapy, Lisa E. Goldsmith and Matthew K. Robinson -- 11 Recombinant bispecific antibodies for cancer therapy, Dafne Muller and Roland Kontermann -- 12 The role of glycosylation in therapeutic antibodies, Maureen Spearman, Ben Dionne and Mike Butler -- 13 Quality issues arising from post-translational modification of recombinant antibodies, Raymond Tyther and Nigel Jenkins -- 14 Purification of antibody, XueJun Han, Arther Hewig and Ganesh Vedantham -- Index.
  note: edited by Mohamed Al-Rubeai.
  subject:
    topic: Medicine
  subject:
    topic: Biomedicine
  subject:
    topic: Biomedicine general
  classification: R-RZ
  classification: 610
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Cell Engineering, 7
  identifier: 9789400712577
  identifier: http://dx.doi.org/10.1007/978-94-007-1257-7
  record info:
    record creation date: 110516
    record change date: 20150519174816.0
    record identifier: 978-94-007-1257-7