rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Biomimetic Membranes for Sensor and Separation Applications
  name:
    name part: Hélix-Nielsen, Claus.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 292 p. online resource.
  abstract: This book addresses the possibilities and challenges in mimicking biological membranes and creating membrane-based sensor and separation devices. It covers recent advances in developing biomimetic membranes for technological applications with a focus on the use of integral membrane protein mediated transport. It describes the fundamentals of biosensing as well as separation and shows how the two processes work together in biological systems. The book provides an overview of the current state of the art, points to areas that need further investigation and anticipates future directions in the field. Biomimetics is a truly cross-disciplinary approach and this is exemplified by the challenges in mimicking osmotic processes as they occur in nature using aquaporin protein water channels as central building blocks. In the development of a biomimetic sensor/separation technology, both channel and carrier proteins are important and examples of how these may be reconstituted and controlled in biomimetic membranes are presented. Also new developments in our understanding of the reciprocal coupling between the material properties of the biomimetic matrix and the embedded proteins are discussed. The basic concepts of membrane barrier properties are introduced and discussed in terms of lipid and polymer based membranes. Once a given protein is reconstituted in its final host biomimetic matrix, its stability needs to be maintained and controlled and the challenges associated with insertion and stabilization of alpha-helical bundle proteins are exemplified with aquaporin and ion channels as well as sodium-potassium ATPase proteins. The concept of multi-scale modeling is introduced and exemplified by the use of molecular dynamics, dissipative particle dynamics, and computational fluid dynamics simulations illustrating the issues involved in developing and describing biomimetic systems in a wide range of time and length scales. Scalability is a general issue for all nano-inspired tec…
  note: edited by Claus Hélix-Nielsen.
  subject:
    topic: Physics
  subject:
    topic: Biochemistry
  subject:
    topic: Biophysics
  subject:
    topic: Biological physics
  subject:
    topic: Membranes (Biology)
    topic: Mechanical properties
  subject:
    topic: Biomedical engineering
  subject:
    topic: Biomaterials
  subject:
    topic: Physics
  subject:
    topic: Membranes
  subject:
    topic: Biochemistry, general
  subject:
    topic: Biomaterials
  subject:
    topic: Biomedical Engineering
  subject:
    topic: Biophysics and Biological Physics
  classification: QH601-602
  classification: QR77
  classification: 571.64
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Biological and Medical Physics, Biomedical Engineering
  identifier: 9789400721845
  identifier: http://dx.doi.org/10.1007/978-94-007-2184-5
  record info:
    record creation date: 120101
    record change date: 20151204162724.0
    record identifier: 978-94-007-2184-5