rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Phosphoinositides II: The Diverse Biological Functions
  name:
    name part: Balla, Tamas.
    role:
      role term: editor.
  name:
    name part: Wymann, Matthias.
    role:
      role term: editor.
  name:
    name part: York, John D.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 460 p. online resource.
  abstract: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, …
  note: edited by Tamas Balla, Matthias Wymann, John D. York.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Medical genetics
  subject:
    topic: Molecular biology
  subject:
    topic: Neurosciences
  subject:
    topic: Neurochemistry
  subject:
    topic: Biomedicine
  subject:
    topic: Biomedicine general
  subject:
    topic: Neurosciences
  subject:
    topic: Human Genetics
  subject:
    topic: Molecular Medicine
  subject:
    topic: Gene Function
  subject:
    topic: Neurochemistry
  classification: R-RZ
  classification: 610
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Subcellular Biochemistry, 59
  identifier: 9789400730151
  identifier: http://dx.doi.org/10.1007/978-94-007-3015-1
  record info:
    record creation date: 120228
    record change date: 20151204143345.0
    record identifier: 978-94-007-3015-1