rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Spotlight on Familial and Hereditary Gastric Cancer
  name:
    name part: Corso, Giovanni.
    role:
      role term: editor.
  name:
    name part: Roviello, Franco.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVIII, 211 p. online resource.
  abstract: In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma.
  table of contents: Foreword -- Preface.-I General Issues -- Historical overview of familial gastric cancer -- Frequency of familial gastric cancer -- The family cancer database.- II Genetics and Epigenetics -- CDH1 gene, structure and function -- E-cadherin germline mutation -- Molecular mechanisms of hereditary diffuse gastric cancer initiation and progression -- Germline missense mutants in hereditary diffuse gastric cancer -- Alternative mechanisms to germline CDH1 mutations in hereditary diffuse gastric cancer -- Beyond CDH1 mutation-causes of hereditary gastric cancer -- Non-CDH1-associated familial gastric cancer and epigenetics factors.-III Pathology -- Hereditary diffuse gastric cancer and lobular breast carcinoma -- Pathology of hereditary diffuse gastric cancer.-IV Management -- Clinical criteria for familial gastric cancer definition -- Prophylactic total gastrectomy in CDH1 germline mutation carrier -- Gastric cancer in other inherited syndromes -- Clinical management of familial gastric cancer.- Appendix.- Index.
  note: edited by Giovanni Corso, Franco Roviello.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Human genetics
  subject:
    topic: Gastroenterology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Biomedicine general
  subject:
    topic: Gastroenterology
  subject:
    topic: Human Genetics
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  identifier: 9789400765702
  identifier: http://dx.doi.org/10.1007/978-94-007-6570-2
  record info:
    record creation date: 130605
    record change date: 20151125211026.0
    record identifier: 978-94-007-6570-2