rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mechanisms of Gene Regulation
  name:
    name part: Carlberg, Carsten.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Molnár, Ferdinand.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2016
    edition: 2nd ed. 2016.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 211 p. 82 illus. in color. online resource.
  abstract: This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chro…
  table of contents: Overview: What is gene expression? -- The impact of chromatin -- The basal transcriptional machinery -- Transcription factors -- Linking signal transduction and gene regulation -- Switching genes on and off at the example of nuclear receptors -- Mapping the genome -- Chromatin modifiers -- Genomic imprinting -- The epigenome -- Chromatin remodeling -- Chromatin architecture -- Regulatory RNA.
  note: by Carsten Carlberg, Ferdinand Molnár.
  subject:
    topic: Medicine
  subject:
    topic: Gene expression
  subject:
    topic: Proteins
  subject:
    topic: Biomedicine
  subject:
    topic: Gene Expression
  subject:
    topic: Protein Structure
  classification: QP110.G45
  classification: 611.01816
  related item:
    title info:
      title: Springer eBooks
  identifier: 9789401777414
  identifier: http://dx.doi.org/10.1007/978-94-017-7741-4
  record info:
    record creation date: 160606
    record change date: 20160606152419.0
    record identifier: 978-94-017-7741-4