rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Angiogenesis and Anti-Angiogenesis in Hematological Malignancies
  name:
    name part: Ribatti, Domenico.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XI, 114 p. 44 illus., 30 illus. in color. online resource.
  abstract: It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.
  table of contents: Preface -- Introduction -- Angiogenesis in multiple myeloma -- Angiogenesis in lymphomas -- Angiogenesis in leukemia -- Antiangiogenesis -- Concluding remarks -- References.
  note: by Domenico Ribatti.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Hematology
  subject:
    topic: Oncology
  subject:
    topic: Life sciences
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Oncology
  subject:
    topic: Hematology
  subject:
    topic: Life Sciences, general
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  identifier: 9789401780353
  identifier: http://dx.doi.org/10.1007/978-94-017-8035-3
  record info:
    record creation date: 140106
    record change date: 20151204190654.0
    record identifier: 978-94-017-8035-3