rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells
  name:
    name part: Zhao, Xiaoyang.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XV, 92 p. 21 illus., 18 illus. in color. online resource.
  abstract: Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson’s disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species, and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications, and increase the current low induction efficiency of their production.
  table of contents: Abstract -- Introduction -- Establishment of highly efficient somatic cell reprogramming system to generate iPSC lines- Establishment of highly efficient somatic cell reprogramming system and establishment of iPSC lines -- Pluripotency of iPSC and underlining mechanism -- Developmental potential of mouse iPSC -- Conclusions.
  note: by Xiaoyang Zhao.
  subject:
    topic: Life sciences
  subject:
    topic: Stem cells
  subject:
    topic: Cell culture
  subject:
    topic: Regenerative medicine
  subject:
    topic: Tissue engineering
  subject:
    topic: Developmental biology
  subject:
    topic: Life Sciences
  subject:
    topic: Stem Cells
  subject:
    topic: Cell Culture
  subject:
    topic: Regenerative Medicine/Tissue Engineering
  subject:
    topic: Developmental Biology
  classification: QH588.S83
  classification: 571.6
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses, Recognizing Outstanding Ph.D. Research
  identifier: 9789401788199
  identifier: http://dx.doi.org/10.1007/978-94-017-8819-9
  record info:
    record creation date: 140519
    record change date: 20151103123606.0
    record identifier: 978-94-017-8819-9