rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level
  name:
    name part: Asson-Batres, Mary Ann.
    role:
      role term: editor.
  name:
    name part: Rochette-Egly, Cécile.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 230 p. 46 illus., 44 illus. in color. online resource.
  abstract: A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I …
  table of contents: Forward -- History of Retinoic Acid Receptors -- Architecture of DNA Bound RAR Heterodimers -- Retinoic Acid Receptors: Structural Basis for Coregulator Interaction and Exchange -- Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling -- RXRs: Collegial Partners -- Nuclear and Extra-Nuclear Effects of Retinoic Acid Receptors: How they are interconnected- The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes -- RARs and micro RNAs -- Integrative genomics to dissect retinoids functions -- Complexity of the RAR‐Mediated Transcriptional Regulatory Programs -- Index.
  note: edited by Mary Ann Asson-Batres, Cécile Rochette-Egly.
  subject:
    topic: Medicine
  subject:
    topic: Science
  subject:
    topic: Gene expression
  subject:
    topic: Nutrition
  subject:
    topic: Health
  subject:
    topic: Biomedicine
  subject:
    topic: Biomedicine general
  subject:
    topic: Gene Expression
  subject:
    topic: Science, general
  subject:
    topic: Nutrition
  subject:
    topic: Medicine/Public Health, general
  subject:
    topic: Popular Science in Medicine and Health
  classification: R-RZ
  classification: 610
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Subcellular Biochemistry, 70
  identifier: 9789401790505
  identifier: http://dx.doi.org/10.1007/978-94-017-9050-5
  record info:
    record creation date: 140624
    record change date: 20151125193003.0
    record identifier: 978-94-017-9050-5