rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Tumor Dormancy, Quiescence, and Senescence, Vol. 3
    sub title: Aging, Cancer, and Noncancer Pathologies
  name:
    name part: Hayat, M.A.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXVI, 144 p. 19 illus. in color. online resource.
  abstract: This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer, and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent, and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes, and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases, and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.
  table of contents: Preface. I General Applications -- Active, dormant, or on the path to elimination: what does a senescent cell do?- Hypoxia and tumor dormancy: can the two tango?- Progeriod syndromes: role of accelerated fibroblast senescence and p38 activation -- Induction of cancer cells senescence: role of caffeic acid 3,4-dihydroxy-phenethyl ester -- II Role in breast cancer -- Various factors contributing to tumor dormancy: therapeutic implications in breast cancer -- Progression of hormone-dependent mammary tumors after dormancy: role of wnt pathway -- III Role in ovarian cancer -- Chemoresistance, dormancy and recurrence in platinum drug therapy of ovarian cancers -- The role of angiogenesis, growth arrest and autophagy in human ovarian cancer xenograft models for tumor dormancy -- Role in leukemia -- Regulation of the promyelocytic leukemia protein and its role in premature senescence -- V Role in cardiovascular disease -- Cardiac senescence and autophagy -- Index.
  note: edited by M.A. Hayat.
  subject:
    topic: Life sciences
  subject:
    topic: Medicine
  subject:
    topic: Life Sciences
  subject:
    topic: Life Sciences, general
  subject:
    topic: Biomedicine general
  subject:
    topic: Medicine/Public Health, general
  classification: QH301-705
  classification: 570
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Tumor Dormancy and Cellular Quiescence and Senescence, Aging, Cancer, and Noncancer Pathologies ; 3
  identifier: 9789401793254
  identifier: http://dx.doi.org/10.1007/978-94-017-9325-4
  record info:
    record creation date: 140912
    record change date: 20150519193624.0
    record identifier: 978-94-017-9325-4