rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Biological Small Angle Scattering: Techniques, Strategies and Tips
  name:
    name part: Chaudhuri, Barnali.
    role:
      role term: editor.
  name:
    name part: Muñoz, Inés G.
    role:
      role term: editor.
  name:
    name part: Qian, Shuo.
    role:
      role term: editor.
  name:
    name part: Urban, Volker S.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: si
    date issued: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 268 p. 87 illus., 77 illus. in color. online resource.
  abstract: This book provides a clear, comprehensible and up-to-date description of how Small Angle Scattering (SAS) can help structural biology researchers. SAS is an efficient technique that offers structural information on how biological macromolecules behave in solution. SAS provides distinct and complementary data for integrative structural biology approaches in combination with other widely used probes, such as X-ray crystallography, Nuclear magnetic resonance, Mass spectrometry and Cryo-electron Microscopy. The development of brilliant synchrotron small-angle X-ray scattering (SAXS) beam lines has increased the number of researchers interested in solution scattering. SAS is especially useful for studying conformational changes in proteins, highly flexible proteins, and intrinsically disordered proteins. Small-angle neutron scattering (SANS) with neutron contrast variation is ideally suited for studying multi-component assemblies as well as membrane proteins that are stabilized in surfactant micelles or vesicles. SAS is also used for studying dynamic processes of protein fibrillation in amyloid diseases, and pharmaceutical drug delivery. The combination with size-exclusion chromatography further increases the range of SAS applications. The book is written by leading experts in solution SAS methodologies. The principles and theoretical background of various SAS techniques are included, along with practical aspects that range from sample preparation to data presentation for publication. Topics covered include techniques for improving data quality and analysis, as well as different scientific applications of SAS. With abundant illustrations and practical tips, we hope the clear explanations of the principles and the reviews on the latest progresses will serve as a guide through all aspects of biological solution SAS. The scope of this book is particularly relevant for structural biology researchers who are new to SAS. Advanced users of the technique will find it helpful for…
  table of contents: Sample and Buffer preparation for SAXS -- Considerations for sample preparation using size-exclusion chromatography -- How to analyze and present SAS data for publication -- Designing and Performing Biological Solution Small-Angle Neutron Scattering Contrast Variation Experiments on Multi-component Assemblies -- SAS-based structural modeling and model validation -- Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering -- What can we learn from wide-angle solution scattering? -- SAS-based studies of protein fibrillation -- High Resolution Distance Distributions Determined by X-ray and Neutron Scattering -- A successful combination: coupling SE-HPLC with SAXS -- Applications of SANS to study membrane protein systems -- Hybrid applications of solution scattering to aid structural biology -- A practical guide to iSPOT modeling: An integrative structural biology platform -- Small angle scattering for pharmaceutical applications: From drugs to drug delivery system.
  note: edited by Barnali Chaudhuri, Inés G. Muñoz, Shuo Qian, Volker S. Urban.
  subject:
    topic: Life sciences
  subject:
    topic: Molecular biology
  subject:
    topic: Biotechnology
  subject:
    topic: Proteins
  subject:
    topic: Life Sciences
  subject:
    topic: Protein Structure
  subject:
    topic: Molecular Medicine
  subject:
    topic: Biotechnology
  classification: QD431-431.7
  classification: 572.633
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Experimental Medicine and Biology, 1009
  identifier: 9789811060380
  identifier: http://dx.doi.org/10.1007/978-981-10-6038-0
  record info:
    record creation date: 171207
    record change date: 20171207214134.0
    record identifier: 978-981-10-6038-0