rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Cancer RNome: Nature & Evolution
  name:
    name part: Arora, Mansi.
    role:
      role term: creator
    role:
      role term: author.
    role:
      role term: aut
    role:
      role term: http://id.loc.gov/vocabulary/relators/aut
  name:
    name part: Kaul, Deepak.
    role:
      role term: author.
    role:
      role term: aut
    role:
      role term: http://id.loc.gov/vocabulary/relators/aut
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: si
    date issued: 2018
    edition: 1st ed. 2018.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 313 p. 51 illus., 50 illus. in color. online resource.
  abstract: In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.
  table of contents: 1. Section 1. RNome: Evolution and nature -- Chapter. 1.1. RNA world hypothesis -- Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions -- 2. Section 2. Cellular RNome: Chromatin dynamics -- Chapter. 2.1. Chromatin modifications & transcription -- Chapter. 2.2. RNA modifications and epitranscriptomics -- Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA -- 3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?) -- Chapter. 3.1. Genome instability and mutation -- Chapter. 3.2. Tumor-promoting inflammation -- Chapter. 3.3. DNA methylation addiction -- Chapter. 3.4. Oncoviruses -- Chapter. 3.5. Sustained proliferative signaling -- Chapter. 3.6. Evasion of growth suppressors -- Chapter. 3.7. Replicative immortality -- Chapter. 3.8. Resisting Cell death -- Chapter. 3.9. Invasion and metastasis -- Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth -- Chapter. 3.12. Tumor Immune-evasion -- Chapter. 3.13. Cancer stem cells and tumor cell plasticity -- 4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers -- Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.
  note: by Mansi Arora, Deepak Kaul.
  subject:
    topic: Cancer research
  subject:
    topic: Human genetics
  subject:
    topic: Molecular biology
  subject:
    topic: Biomedical engineering
  subject:
    topic: Laboratory medicine
  subject:
    topic: Cancer Research
  subject:
    topic: Human Genetics
  subject:
    topic: Molecular Medicine
  subject:
    topic: Biomedical Engineering/Biotechnology
  subject:
    topic: Laboratory Medicine
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  identifier: 9789811315688
  identifier: https://doi.org/10.1007/978-981-13-1568-8
  record info:
    record creation date: 181102
    record change date: 20191028142251.0
    record identifier: 978-981-13-1568-8