rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules
    sub title: The Shape of Organic Synthesis to Come
  name:
    name part: Kobayashi, Yuichi.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: si
    date issued: 2019
    edition: 1st ed. 2019.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXV, 355 p. 406 illus., 127 illus. in color. online resource.
  abstract: This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.
  table of contents: 1. Microbial Fraction Library: A Screening Source for Drug Discovery -- 2. Efficient Total Synthesis of Ōmura Natural Products -- 3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol -- 4. Synthetic Approaches on the Pluramycin-class Antibiotics -- 5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and -II -- 6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis -- 7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications -- 8. Total Synthesis of Ingenol -- 9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids -- 10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid -- 11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds -- 12. Exploring bioactive marine natural products and identification of their molecular targets -- 13. Target protein chemical modification -- 14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes.
  note: edited by Yuichi Kobayashi.
  subject:
    topic: Organic chemistry
  subject:
    topic: Medicinal chemistry
  subject:
    topic: Pharmacy
  subject:
    topic: Organic Chemistry
  subject:
    topic: Medicinal Chemistry
  subject:
    topic: Pharmacy
  classification: QD415-436
  classification: 547
  related item:
    title info:
      title: Springer eBooks
  identifier: 9789811362446
  identifier: https://doi.org/10.1007/978-981-13-6244-6
  record info:
    record creation date: 190530
    record change date: 20191220125603.0
    record identifier: 978-981-13-6244-6