rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Therapeutic Enzymes: Function and Clinical Implications
  name:
    name part: Labrou, Nikolaos.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: si
    date issued: 2019
    edition: 1st ed. 2019.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VIII, 386 p. 90 illus., 71 illus. in color. online resource.
  abstract: This edited work presents studies that clarify several aspects of the development and application of therapeutic enzymes. Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This book covers mainly three areas of recombinant therapeutic enzymes and their clinical and pharmaceutical technology: (i) overview of the production process and biochemical characterization of therapeutic enzymes, (ii) focuses upon the engineering strategies and delivery methods of therapeutic enzymes, (iii) clinical applications of selected therapeutic enzymes, including aspects on their mechanisms of action and information on safety, immunogenicity issues and various adverse events of the enzymes used for therapy. The topic of this book is particularly relevant to academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.
  table of contents: Chapter 1. Introduction to therapeutic enzymes -- Chapter 2. Upstream processing technologies -- Chapter 3. Downstream processing technologies -- Chapter 4. Enzyme Manufacturing Process and Quality Control Evaluations -- Chapter 5. Regulatory guidance in the production of therapeutic enzymes -- Chapter 6. Biophysical methods for the characterization of Enzyme Therapeutics Bertrand Raynal Patrick England -- Chapter 7. Clinical Development of a therapeutic enzyme -- Chapter 8. Chemical modifications of therapeutic proteins -- Chapter 9. Formulation of therapeutic enzymes -- Chapter 10. Engineering of therapeutic enzymes for improving activity -- Chapter 11. Engineering of therapeutic enzymes for improving stability -- Chapter 12. Design and engineering of deimmunized therapeutic enzymes -- Chapter 13. Nanoparticles for delivery of therapeutic enzymes -- Chapter 14. Targeted delivery of therapeutic enzymes -- Chapter 15. Oral and inhalable enzyme therapies -- Chapter 16. Regulatory issues -- Chapter 17. Enzyme replacement therapies -- Chapter 18. Pharmacodynamics and pharmacokinetics issues of enzyme replacement therapy -- Chapter 19. Enzyme therapy for lysosomal storage disorders -- Chapter 20. Enzyme therapy for myocardial infarction -- Chapter 21. Enzyme therapy for chronic gout -- Chapter 22. Enzyme therapy for tumor lysis syndrome -- Chapter 23. Enzyme therapy for collagen-based disorders -- Chapter 24. Enzyme therapy for severe combined immunodeficiency disease -- Chapter 25. Enzyme therapy for detoxification of methotrexate -- Chapter 26. Enzyme therapy vitreomacular adhesion -- Chapter 27. L-Asparaginase as anticancer agent -- Chapter 28. Pancreatic enzyme replacement therapy -- Chapter 29. Enzymes in metabolic anticancer therapy -- Chapter 30. L-Arginase for L-Arg depletion therapy in cancer -- Chapter 31. Methionine L-lyase for L-Met depletion therapy in cancer -- Chapter 32. Enzyme therapy for celiac sprue -- Chapter 33. Acid ceramidase -- Chapter 34. Lysoso…
  note: edited by Nikolaos Labrou.
  subject:
    topic: Proteins
  subject:
    topic: Protein Science
  classification: QD431-431.7
  classification: 572.6
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Experimental Medicine and Biology, 1148
  identifier: 9789811377099
  identifier: https://doi.org/10.1007/978-981-13-7709-9
  record info:
    record creation date: 190903
    record change date: 20191022072440.0
    record identifier: 978-981-13-7709-9