http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xv, 344 pages, 8 unnumbered pages of plates) : illustrations (some color).
A great deal of progress has been made in defining GABA (gamma-aminobutyric acid) transmission in the brain. Volume 54 of the Advances in Pharmacology series has also provided new insights into fundamental features of neurotransmission in general, such as the importance of allosterism and coincident signaling in regulating receptor function and overall cellular activity. These studies have led to the design and development of new drugs and potential therapeutic agents. Given the successes achieved over the first 50 years of GABA research, it is certain the 6th decade will yield its share of surprising discoveries and new insights. Published in this volume are articles providing thoughts and perspectives on this topic, some with the benefit of hindsight, others in the context of recent findings, but all with a hint, or prediction, of what the future holds as the secrets of GABA neurotransmission continue to unfold.
The Role of GABA in the Mediation and Perception of Pain -- Distribution of GABA Receptors in the Thalamus and Their Involvement in Nociception -- GABAA Agonists and Partial Agonists: THIP (Gaboxadol) as a Non-Opioid Analgesic and a Novel Type of Hypnotic1 -- Rat Modeling for GABA Defects in Schizophrenia -- Epigenetic Targets in GABAergic Neurons to Treat Schizophrenia -- GABAergic Malfunction in the Limbic System Resulting from an Aboriginal Genetic Defect in Voltage-Gated Na+-Channel SCN5A is Proposed to Give Rise to Susceptibility to Schizophrenia -- GABAA Receptor Mutations Associated with Generalized Epilepsies1 -- From Gene to Behavior and Back Again: New Perspectives on GABAA Receptor Subunit Selectivity of Alcohol Actions1 -- A Role for GABA in Alcohol Dependence1 -- Structure, Pharmacology, and Function of GABAA Receptor Subtypes -- Structure-Activity Relationship and Pharmacology of [gamma]-Aminobutyric Acid (GABA) Transport Inhibitors -- Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin.
Includes bibliographical references and index.
San Diego : Academic Press/Elsevier, ©2006
Advances in pharmacology (San Diego, Calif.) ; v. 54