rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Recent Advances in Electron Cryomicroscopy
    part number: Part A
  name:
    name part: Ludtke, Steven J.
    role:
      role term: editor.
  name:
    name part: Prasad, B. V. Venkataram
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  genre: Methods (Music)
  origin info:
    place:
      place term: enk
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (vi, 132 pages) : illustrations.
  abstract: Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission.
  table of contents: From envelopes to atoms: the remarkable progress of biological electron microscopy -- Present and future of membrane protein structure determination by electron crystallography -- Single-particle applications at intermediate resolution -- Visualizing molecular machines in action: single-particle analysis with structural variability.
  note: edited by Steven J. Ludtke and B.V. Venkataram Prasad.
  note: Text in English.
  note: Includes bibliographical references and index.
  subject:
    topic: Cryomicroscopy
  subject:
    topic: Electron microscopy
  subject:
    topic: Proteins
    topic: Structure
  subject:
    topic: Biochemistry
    topic: Methods
  subject:
    topic: SCIENCE
    topic: Electron Microscopes & Microscopy
  subject:
    topic: Biochemistry
  subject:
    topic: Cryomicroscopy
  subject:
    topic: Electron microscopy
  subject:
    topic: Proteins
    topic: Structure
  classification: QH225 .R43 2010eb
  classification: 502.8/25
  related item:
    title info:
      title: Recent advances in electron cryomicroscopy. Part A
    origin info:
      publisher: Amsterdam ; Boston : Academic Press/E;sevoer, ©2010
    identifier: (OCoLC)695894457
  related item:
    title info:
      title: Advances in protein chemistry and structural biology ; v. 81
  identifier: 9780123813589
  identifier: 0123813581
  identifier: 9780123813572
  identifier: 0123813573
  identifier: 128295489X
  identifier: 9781282954892
  identifier: https://www.sciencedirect.com/science/bookseries/18761623/81
  record info:
    record content source: N$T
    record creation date: 110216
    record change date: 20180501121939.0
    record identifier: ocn702149330
    language of cataloging:
      language term: eng