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Progress in molecular biology and translational science
Proteases occur naturally in all organisms. They are enzymes which are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields.
Front Cover; Progress in Molecular Biology and Translational Science: Proteases in Health and Disease; Copyright Page; Contents; Contributors; Preface; Chapter 1: Membrane-Anchored Serine Proteases in Health and Disease; I. Introduction; II. Structural Features; III. Regulation by Endogenous Inhibitors; IV. The Type I Transmembrane Serine Protease; V. The Type II Transmembrane Serine Proteases; VI. The GPI-Anchored Serine Proteases; VII. Perspectives; Acknowledgments; References.
Chapter 2: Complex Assemblies of Factors IX and X Regulate the Initiation, Maintenance, and Shutdown of Blood CoagulationI. Introduction; II. Proteolytic Activation of Trypsin-Like Serine Proteases; III. Low-Molecular Weight Cofactors; IV. Protein Cofactors; V. Membranes: Nonhumoral Cofactors of Coagulation Factors; VI. Protein Inhibitors of Coagulation Factors; VII. Pharmaceutical Opportunities and Challenges; Acknowledgments; References; Chapter 3: Structure and Proteolytic Properties of ADAMTS13, A Metalloprotease Involved in the Pathogenesis of Thrombotic Microangiopathies.
I. IntroductionII. Gene, Biosynthesis and Secretion of ADAMTS13; III. ADAMTS13 Structure and Function: General Aspects; IV. ADAMTS13: A Multidomain Enzyme; V. Regulation of ADAMTS13 Activity; VI. ADAMTS13 and Its Role in the Pathogenesis of Thrombotic Microangiopathy, A Pleiomorphic Clinical Setting; VII. Are ADAMTS13 Changes Always Associated with Thrombotic Microangiopathies?; VIII. Issues Concerning Laboratory Methods Used to Measure the ADAMTS13 Activity in Clinical Samples; IX. Future Directions; References; Chapter 4: Thrombin as an Anticoagulant; I. Preamble; II. Thrombin Interactions.
III. Thrombin StructureIV. Thrombin is an Allosteric Enzyme; V. Structures of E*, E, and E:Na+; VI. Dissociating Procoagulant and Anticoagulant Activities; VII. WE: A Prototypic Anticoagulant Thrombin; VIII. Molecular Mechanism of Anticoagulant Activity of Thrombin Mutants; IX. Beyond WE; X. Conclusions; Acknowledgments; References; Chapter 5: Regulation of Proteases by Protein Inhibitors of the Serpin Superfamily; I. Overview of the Serpin Superfamily; II. Mechanism of Action; III. Rates of Reaction, Specificity, and Regulation; IV. Engineering Serpins as Therapeutics; V. Concluding Remarks.
Includes bibliographical references and index.
Progress in molecular biology and translational science Vol. 99, Proteases in health and disease