rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Progress in molecular biology and translational science
    part number: Vol. 99
    part name: Proteases in health and disease
  name:
    name part: Di Cera, Enrico.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: cau
    place:
      place term: San Diego, CA
    publisher: Academic Press
    date issued: ©2011
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xii, 313 pages)
  abstract: Proteases occur naturally in all organisms. They are enzymes which are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields.
  table of contents: Front Cover; Progress in Molecular Biology and Translational Science: Proteases in Health and Disease; Copyright Page; Contents; Contributors; Preface; Chapter 1: Membrane-Anchored Serine Proteases in Health and Disease; I. Introduction; II. Structural Features; III. Regulation by Endogenous Inhibitors; IV. The Type I Transmembrane Serine Protease; V. The Type II Transmembrane Serine Proteases; VI. The GPI-Anchored Serine Proteases; VII. Perspectives; Acknowledgments; References.
  table of contents: Chapter 2: Complex Assemblies of Factors IX and X Regulate the Initiation, Maintenance, and Shutdown of Blood CoagulationI. Introduction; II. Proteolytic Activation of Trypsin-Like Serine Proteases; III. Low-Molecular Weight Cofactors; IV. Protein Cofactors; V. Membranes: Nonhumoral Cofactors of Coagulation Factors; VI. Protein Inhibitors of Coagulation Factors; VII. Pharmaceutical Opportunities and Challenges; Acknowledgments; References; Chapter 3: Structure and Proteolytic Properties of ADAMTS13, A Metalloprotease Involved in the Pathogenesis of Thrombotic Microangiopathies.
  table of contents: I. IntroductionII. Gene, Biosynthesis and Secretion of ADAMTS13; III. ADAMTS13 Structure and Function: General Aspects; IV. ADAMTS13: A Multidomain Enzyme; V. Regulation of ADAMTS13 Activity; VI. ADAMTS13 and Its Role in the Pathogenesis of Thrombotic Microangiopathy, A Pleiomorphic Clinical Setting; VII. Are ADAMTS13 Changes Always Associated with Thrombotic Microangiopathies?; VIII. Issues Concerning Laboratory Methods Used to Measure the ADAMTS13 Activity in Clinical Samples; IX. Future Directions; References; Chapter 4: Thrombin as an Anticoagulant; I. Preamble; II. Thrombin Interactions.
  table of contents: III. Thrombin StructureIV. Thrombin is an Allosteric Enzyme; V. Structures of E*, E, and E:Na+; VI. Dissociating Procoagulant and Anticoagulant Activities; VII. WE: A Prototypic Anticoagulant Thrombin; VIII. Molecular Mechanism of Anticoagulant Activity of Thrombin Mutants; IX. Beyond WE; X. Conclusions; Acknowledgments; References; Chapter 5: Regulation of Proteases by Protein Inhibitors of the Serpin Superfamily; I. Overview of the Serpin Superfamily; II. Mechanism of Action; III. Rates of Reaction, Specificity, and Regulation; IV. Engineering Serpins as Therapeutics; V. Concluding Remarks.
  note: edited by Enrico Di Cera.
  note: Includes bibliographical references and index.
  subject:
    topic: Proteolytic enzymes
  subject:
    topic: Protease inhibitors
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Zoology
    topic: Mammals
  subject:
    topic: NATURE
    topic: Animals
    topic: Mammals
  subject:
    topic: Protease inhibitors
  subject:
    topic: Proteolytic enzymes
  classification: QP609.P78 P76 2011eb
  classification: 599/.019256
  related item:
    title info:
      title: Progress in molecular biology and translational science Vol. 99, Proteases in health and disease
    origin info:
      publisher: San Diego, CA : Academic Press, ©2011
    identifier: (OCoLC)681501648
  identifier: 9780123855053
  identifier: 0123855055
  identifier: 9780123855046
  identifier: 0123855047
  identifier: https://www.sciencedirect.com/science/bookseries/18771173/99
  record info:
    record content source: N$T
    record creation date: 110302
    record change date: 20180501121940.0
    record identifier: ocn704574500
    language of cataloging:
      language term: eng