rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Antiviral drug strategies
  name:
    name part: De Clercq, Erik.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: gw
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xx, 406 pages) : illustrations (some color).
  abstract: By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de.
  table of contents: Outlook of the antiviral drug era, now more than 50 years after description of the first antiviral drug / Erik De Clercq -- Inhibition of HIV entry / José A. Esté -- Targeting integration beyond strand transfer: development of second-generation HIV integrase inhibitors / Arnout R.D. Voet, Marc De Maeyer, Frauke Christ, Zeger Debyser -- From saquinavir to darunavir: the impact of 10 years of medicinal chemistry on a lethal disease / Marie-Pierre de Béthune, Anik Peeters, Piet Wigerinck -- Acyclic and cyclic nucleoside phosphonates / Richard L. Mackman, Tomas Cihlar -- Helicase-primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus / Subhajit Biswas, Hugh J. Field -- Cyclophilin inhibitors / Grégoire Vuagniaux, Arnaud Hamel, Rafael Crabbé, Hervé C. Porchet, Jean-Maurice Dumont -- Alkoxyalkyl ester prodrugs of antiviral nucleoside phosphates and phosphonates / James R. Beadle, Karl Y. Hostetler -- Maribavir: a novel benzimidazole ribonucleoside for the prevention and treatment of cytomegalovirus diseases / Karen K. Biron -- Anti-HCMV compounds / Graciela Andrei, Robert Snoeck -- Lethal mutagenesis as an unconventional approach to combat HIV / Pinar Iyidogan, Karen S. Anderson -- Recent progress in the development of HCV protease inhibitors / Nagraj Mani, Bhisetti G. Rao, Tara L. Kieffer, Ann D. Kwong -- Antiviral RNAi: how to silence viruses / Karin J. von Eije, Ben Berkhout -- Neuraminidase inhibitors as anti-influenza agents / Willard Lew, Michael Z. Wang, Xiaowu Chen, James F. Rooney, Choung Kim -- From TIBO to rilpivirine: the chronicle of the discovery of the ideal nonnucleoside reverse transcriptase inhibitor / Erik De Clercq.
  note: edited by Erik De Clercq.
  note: Includes bibliographical references and index.
  subject:
    topic: Antiviral agents
    topic: Development
  subject:
    topic: Antiviral agents
    topic: Development
  subject:
    topic: MEDICAL
    topic: Pharmacology
  subject:
    topic: Antiviral Agents
  subject:
    topic: Drug Discovery
  classification: RS431.A66 A68 2011
  classification: 615.7924
  classification: QV268.5
  related item:
    title info:
      title: Antiviral drug strategies
    origin info:
      publisher: Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2011
    identifier: (OCoLC)664325845
  related item:
    title info:
      title: Methods and principles in medicinal chemistry ; v. 50
  identifier: 9783527635955
  identifier: 3527635955
  identifier: 9783527635979
  identifier: 3527635971
  identifier: 1283140918
  identifier: 9781283140911
  identifier: 9783527326969
  identifier: 3527326960
  identifier: 9783527635962
  identifier: 3527635963
  identifier: 9783527635986
  identifier: 352763598X
  identifier: 10.1002/9783527635955 Wiley InterScience
  identifier: https://doi.org/10.1002/9783527635955
  record info:
    record content source: DG1
    record creation date: 110609
    record change date: 20170124072404.9
    record identifier: ocn729726279
    language of cataloging:
      language term: eng