rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Cancer as a metabolic disease
    sub title: on the origin, management, and prevention of cancer
  name:
    name part: Seyfried, Thomas N.
    name part: 1946-
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (472 pages)
  abstract: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requiring metabolic solutions for its management and prevention.
  table of contents: Cancer as a Metabolic Disease; Contents; Foreword; Preface; 1. Images of Cancer; How Cancer is Viewed; References; 2. Confusion Surrounds the Origin of Cancer; The Oncogenic Paradox; Hallmarks of Cancer; Reassessment; References; 3. Cancer Models; Problems with Some Cancer Models; Animal Charges as a Major Impediment to Cancer Research; Problems with Tumor Histological Classification; Personal Perspective on Cancer; References; 4. Energetics of Normal Cells and Cancer Cells; Metabolic Homeostasis; The Constancy of the D G'ATP; ATP Production in Normal Cells and Tumor Cells.
  table of contents: Energy Production Through Glucose Fermentation; Glutaminolysis with or without Lactate Production; Transamination Reactions; TCA Cycle, Substrate-Level Phosphorylation; Cholesterol Synthesis and Hypoxia; Summary; References; 5. Respiratory Dysfunction in Cancer Cells; Normal Mitochondria; Morphological Defects in Tumor Cell Mitochondria; Proteomic Abnormalities in Tumor Cell Mitochondria; Lipidomic Abnormalities in Tumor Cell Mitochondria; Cardiolipin: A Mitochondrial-Specific Lipid; Cardiolipin and Abnormal Energy Metabolism in Tumor Cells.
  table of contents: Complicating Influence of the In Vitro Growth Environment on Cardiolipin Composition and Energy Metabolism; Mitochondrial Uncoupling and Cancer; Cancer Cell Heat Production and Uncoupled Mitochondria; Personal Perspective; Summary; References; 6. The Warburg Dispute; Sidney Weinhouse's Criticisms of the Warburg Theory; Alan Aisenberg's Criticisms of the Warburg Theory; Sidney Colowick's Assessment of the Aisenberg Monograph; Apples and Oranges; References; 7. Is Respiration Normal in Cancer Cells?; Pseudo-Respiration.
  table of contents: How Strong is the Scientific Evidence Showing that Tumor Cells can Produce Energy Through OxPhos?; OxPhos Origin of ATP in Cancer Cells Reevaluated; What About OxPhos Expression in Other Tumors?; The Pedersen Review on Tumor Mitochondria and the Bioenergetics of Cancer Cells; References; 8. Is Mitochondrial Glutamine Fermentation a Missing Link in the Metabolic Theory of Cancer?; Amino Acid Fermentation can Maintain Cellular Energy Homeostasis During Anoxia; Evidence Suggesting that Metastatic Mouse Cells Derive Energy from Glutamine Fermentation.
  table of contents: Fermentation Energy Pathways can Drive Cancer Cell Viability Under Hypoxia; Competing Explanations for the Metabolic Origin of Cancer; Chapter Summary; References; 9. Genes, Respiration, Viruses, and Cancer; Does Cancer have a Genetic Origin?; Respiratory Insufficiency as the Origin of Cancer; Germline Mutations, Damaged Respiration, and Cancer; Somatic Mutations and Cancer; Revisiting the Oncogene Theory; Mitochondrial Mutations and the Absence or Presence of Cancer; Viral Infection, Damaged Respiration, and the Origin of Cancer; Summary; References.
  table of contents: 10. Respiratory Insufficiency, the Retrograde Response, and the Origin of Cancer.
  note: Thomas Seyfried.
  note: Includes bibliographical references and index.
  subject:
    topic: Cancer
    topic: Prevention
  subject:
    topic: Neoplasms
    topic: diet therapy
  subject:
    topic: Neoplasms
    topic: metabolism
  subject:
    topic: Energy Metabolism
  subject:
    topic: Ketogenic Diet
  subject:
    topic: Mitochondria
    topic: metabolism
  subject:
    topic: Medicine
  subject:
    topic: MEDICAL
    topic: Oncology
  subject:
    topic: Cancer
    topic: Prevention
  classification: RC262 .S49 2012
  classification: QZ200
  classification: 616.99 616.9940564
  classification: QZ 200
  related item:
    title info:
      title: Cancer as a Metabolic Disease : On the Origin, Management, and Prevention of Cancer
    name:
      name part: Seyfried, Thomas N., 1946-
    origin info:
      publisher: Hoboken : John Wiley & Sons, ©2012
  identifier: 9781118310311
  identifier: 1118310314
  identifier: 9781118310298
  identifier: 1118310292
  identifier: 9781118310304
  identifier: 1118310306
  identifier: 9780470584927
  identifier: 0470584920
  identifier: EB00063323 Recorded Books
  identifier: 9CB1EADD-C87E-47D5-8E45-0D6294D5C400 OverDrive, Inc.
  identifier: https://doi.org/10.1002/9781118310311
  record info:
    record content source: EBLCP
    record creation date: 120521
    record change date: 20170124070439.6
    record identifier: ocn793995949
    language of cataloging:
      language term: eng