rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Comparative pathophysiology and toxicology of cyclooxygenases
  name:
    name part: Radi, Zaher A.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks. Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing, COX inhibitors and renal system pathophysiology and mechanisms of toxicity, The pathophysiologic role of COX inhibition in the ocular system, COX inhibition and the respiratory and cardiovascular systems. The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.
  note: Zaher A. Radi.
  note: Includes bibliographical references and index.
  subject:
    topic: Cyclooxygenases
    topic: Pathophysiology
  subject:
    topic: Cyclooxygenases
    topic: Toxicology
  subject:
    topic: MEDICAL
    topic: Toxicology
  subject:
    topic: Science
  classification: RA1242.D46 .R33 2012eb
  classification: 615.9/5137
  classification: WA 671
  related item:
    identifier: (DLC) 2012002908
  identifier: 9781118351918
  identifier: 1118351916
  identifier: 9781118351888
  identifier: 1118351886
  identifier: 9781118351901
  identifier: 1118351908
  identifier: 9780470577547
  identifier: 0470577541
  identifier: 2012002908
  identifier: EB00063407 Recorded Books
  identifier: 388852 MIL
  identifier: https://doi.org/10.1002/9781118351918
  record info:
    record content source: CDX
    record creation date: 120229
    record change date: 20170124071116.2
    record identifier: ocn808867147
    language of cataloging:
      language term: eng