rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Flavonoid pharmacokinetics
    sub title: methods of analysis, preclinical and clinical pharmacokinetics, safety, and toxicology
  name:
    name part: Davies, Neal M.
  name:
    name part: Yáñez, Jaime A.
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: xx
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (356 pages)
  abstract: Highlighting the extremely important preclinical aspects of flavonoids, including pharmacokinetics and analysis in biological samples, Flavonoid Pharmacokinetics covers the methods of analysis and pharmacokinetics (preclinical and clinical) of flavonoids to help readers comprehend pharmacokinetic terminology, understand the large number of compounds that encompass the flavonoid family, appreciate the multiple analytical methods available, and assess preclinical and clinical pharmacokinetics of flavonoids and similar chemical-derived compounds. The book uses applicable examples in differ.
  table of contents: Title page; Copyright page; Dedication; Contents; Foreword; Preface; Contributors; 1: Polyphenols and Flavonoids: An Overview; 1.1 Introduction; 1.2 Synthesis; 1.2.1 Synthesis of Flavonoids; 1.3 Sources; 1.4 Pharmacological Activities of Selected Flavonoids; 1.4.1 Hesperidin and Hesperetin; 1.4.2 Naringin and Naringenin; 1.4.3 Eriocitrin and Eriodictyol; 1.4.4 Phloretin; 1.4.5 Homoeriodictyol; 1.4.6 Isosakuranetin; 1.4.7 Taxifolin; 1.4.8 Sakuranetin; 1.4.9 Gallic Acid; 1.5 Conclusions; References; 2: Analysis of Flavonoids through Chromatography; 2.1 Introduction; 2.2 Polyphenols.
  table of contents: 2.3 Chromatography2.3.1 Chromatographic Techniques; 2.3.2 Affinity Chromatography; 2.3.3 Ion-Exchange Chromatography; 2.3.4 Partition (Absorption); 2.3.5 Adsorption; 2.3.6 Paired Chromatography; 2.4 Detection; 2.4.1 Ultraviolet-Visible/Photodiode Array Detection; 2.4.2 Fluorescence Detection; 2.4.3 Mass Spectrometry; 2.4.4 Nuclear Magnetic Resonance; 2.4.5 Other Methods and Techniques; 2.5 Method Development; 2.5.1 Physicochemical Properties; 2.5.2 Mobile Phase; 2.5.3 Stationary Phase; 2.5.4 Internal and External Standards; 2.5.5 Processing; 2.6 Validation; 2.6.1 Peak Shape and Distribution.
  table of contents: 2.6.2 Selectivity, Sensitivity, Accuracy, Precision, and Recovery2.6.3 Stability; 2.7 Summary; 2.8 Future Directions; 2.9 Conclusions; References; 3: Chiral Methods of Flavonoid Analysis; 3.1 Introduction; 3.2 Flavonoids and Chirality; 3.3 Separation of Enantiomers through Chromatography; 3.3.1 Chiral Stationary Phases (CSP) as Direct Methods; 3.3.2 Chiral Derivatization Techniques and Indirect Analysis; 3.4 Enantiomerization and Racemization; 3.5 Current Methods: Pros and Cons; 3.6 Flavanones; 3.6.1 Eriocitrin and Eriodictyol; 3.6.2 Flavanone; 3.6.3 Hesperidin and Hesperetin.
  table of contents: 3.6.4 Homoeriodictyol3.6.5 Isosakuranetin; 3.6.6 Liquiritigenin; 3.6.7 Naringin and Naringenin; 3.6.8 Narirutin; 3.6.9 Neoeriocitrin; 3.6.10 Neohesperidin; 3.6.11 Pinocembrin; 3.6.12 Pinostrobin; 3.6.13 Prunin; 3.6.14 Sakuranetin; 3.6.15 Taxifolin; 3.6.16 6-Prenylnaringenin, 8-Prenylnaringenin, and Isoxanthohumol; 3.7 Catechins; 3.7.1 Catechin; 3.7.2 Catechin Gallate; 3.7.3 Epicatechin; 3.7.4 Epicatechin Gallate; 3.7.5 Epigallocatechin; 3.7.6 Epigallocatechin Gallate; 3.7.7 Gallocatechin; 3.8 Conclusions; References; 4: Preclinical Pharmacokinetics of Flavonoids; 4.1 Introduction.
  table of contents: 4.2 Absorption4.3 Distribution; 4.4 Metabolism; 4.5 Excretion; 4.6 Conclusions; References; 5: Clinical Pharmacokinetics of Flavonoids; 5.1 Introduction; 5.2 Methods of Analysis; 5.3 Flavonoid Pharmacokinetics; 5.3.1 Nonchiral Flavonoids; 5.3.2 Chiral Flavonoids; 5.3.3 Flavonoid Derivatives; 5.4 Drug Interactions; 5.4.1 Effects of Flavonoids on Other Drug Pharmacokinetics; 5.4.2 Effects of Other Drugs on Flavonoid Pharmacokinetics; 5.5 Conclusions; References; 6: Toxicology and Safety of Flavonoids; 6.1 Introduction; 6.2 Flavonoids and the Gastrointestinal Tract; 6.2.1 Diarrhea; 6.2.2 Colitis.
  note: edited by Neal M. Davies, Jaime A. Yáñez.
  note: 6.3 Flavonoids and Hepatic Side Effects.
  subject:
    topic: Flavonoids
  subject:
    topic: Pharmacokinetics
  subject:
    topic: MEDICAL
    topic: Pharmacology
  subject:
    topic: Flavonoids
  subject:
    topic: Pharmacokinetics
  classification: QK898.F5 F53 2013eb
  classification: 615.7
  related item:
    title info:
      title: Flavonoid Pharmacokinetics : Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology
    name:
      name part: Davies, Neal M.
    origin info:
      publisher: Chicester : Wiley, ©2012
  identifier: 9781118468524
  identifier: 111846852X
  identifier: 9781118354391
  identifier: 1118354397
  identifier: https://doi.org/10.1002/9781118468524
  record info:
    record content source: EBLCP
    record creation date: 121120
    record change date: 20170124072440.4
    record identifier: ocn818819707
    language of cataloging:
      language term: eng