rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Advances in immunology
    part number: Volume 119
  name:
    name part: Alt, Frederick W.
    role:
      role term: editor.
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field.
  table of contents: Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: The Interdisciplinary Science of T-cell Recognition; 1. Introduction; 2. The First Level of Complexity: The Kinetics and Structural Basis of TCR-pMHC Engagement; 2.1. A corner stone of T-cell biology: Kinetic and thermodynamic measurements of TCR-pMHC binding in vitro; 2.2. TCR-pMHC structure as the gold standard: Docking geometry, germline bias, and CDR3 loops; 2.3. Implications: Cross-reactivity and serial triggering.
  table of contents: 3. The Second Level of Complexity: The TCR-CD3 Complex and Approaches to Answers of How It Works3.1. Toward a structural understanding of the TCR-CD3 complex; 3.2. Do allosteric interactions pull the trigger?; 3.3. Coreceptor-mediated T-cell triggering?; 3.4. Formation of higher order TCR-CD3 complex structures as the defining trigger event?; 4. The Third Level of Complexity: Antigen Recognition and the Immunological Synapse; 4.1. Binding within the synapse and expected consequences; 4.2. Mechanical assays to measure 2D-kinetics; 4.3. Imaging TCR-pMHC interactions in situ.
  table of contents: 4.4. Synaptic factors influencing T-cell antigen recognition and activation5. Perspective; Acknowledgments; References; Chapter Two: Residual Immune Dysregulation Syndrome in Treated HIV infection; 1. The Role of Activation and Inflammation in the Natural History of Infection; 2. Inflammatory and Coagulation Indices Predict Morbidity in Treated HIV Infection; 3. Persistent CD4+ T Cell Lymphopenia Predicts Clinical Outcomes During ART; 4. Immune Activation/Inflammation Predicts Morbidity and Mortality During ART; 5. Failure to Restore Circulating CD4+ T Cells in HIV Infection.
  table of contents: 6. The LN in Treated HIV Infection7. The Gut in Treated HIV Infection; 8. Other Possible Drivers of Residual Immune Dysregulation in Treated HIV Infection; 8.1. Microbial translocation; 8.2. Homeostatic proliferation; 8.3. HIV replication; 8.4. Copathogens; 8.5. Inflammatory lipids; 9. Therapeutic Approaches; 9.1. Targeting residual viral replication; 9.2. Targeting chronic viral coinfections; 9.3. Targeting microbial translocation; 9.4. Interventions to improve CD4+ T cell recovery; 9.5. Targeting innate immune responses; 10. Summary; Acknowledgment; References.
  table of contents: Chapter Three: Developmental Plasticity of Murine and Human Foxp3+ Regulatory T Cells1. Introduction; 2. Stability and Plasticity of Regulatory T Cells; 2.1. Homeostatic stability of Foxp3+ regulatory T cells; 2.2. Programmed plasticity of Foxp3+ regulatory T cells; 3. A Transient Flexibility Model for Regulatory T Cell Plasticity; 3.1. Enhanced regulatory T cell plasticity during the initiation phase of infection; 3.2. Regulatory T cell stability during the active phase of infection; 3.3. Transient Treg cell development during the resolution phase of infection.
  note: edited by Frederick Alt.
  subject:
    topic: Immunology
  subject:
    topic: MEDICAL
    topic: Immunology
  subject:
    topic: Health and Wellbeing
  subject:
    topic: Immunology
  classification: QR181
  classification: 616.079
  classification: QW 504
  related item:
    title info:
      title: Advances in immunology. Volume 119
    identifier: (OCoLC)853505665
  related item:
    title info:
      title: Advances in immunology ; v. 119
  identifier: 9780124077355
  identifier: 0124077358
  identifier: 9780124077072
  identifier: 0124077072
  identifier: https://www.sciencedirect.com/science/bookseries/00652776/119
  record info:
    record content source: N$T
    record creation date: 130731
    record change date: 20180501122012.0
    record identifier: ocn854760796
    language of cataloging:
      language term: eng