rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mechanotransduction
  name:
    name part: Engler, Adam J.
  name:
    name part: Kumar, Sanjay.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: vtu
    place:
      place term: Burlington
    publisher: Elsevier Science
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (404 pages).
  abstract: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique.
  table of contents: Front Cover; Mechanotransduction; Copyright; Contents; Contributors; Preface; Part One: Subcellular Tools for Activating and Measuring Mechanotransductive Signaling; Chapter One: The Detection and Role of Molecular Tension in Focal Adhesion Dynamics; 1. Brief Introduction to Mechanobiology; 2. Focal Adhesions in Mechanosensing; 2.1. Focal adhesion structure; 2.2. Molecular mechanisms of mechanotransduction; 3. Design and Use of Optically Based Molecular Tension Sensors; 3.1. Basics of Forster Resonance Energy Transfer (FRET); 3.2. Designs of FRET-based force-sensitive biosensors.
  table of contents: 3.2.1. Extensible domain3.2.2. Rotatable domain; 3.2.3. Other designs; 3.3. Use of FRET-based tension sensors: Relative versus absolute measurements; 3.4. Critical control experiments and assumptions involved in the creation and use of FRET-based biosensors; 3.5. Conformation sensors versus tension sensors; 4. The Role of Molecular Tension in Focal Adhesion Dynamics; 5. Future Outlook; Acknowledgments; References; Chapter Two: Single-Cell Imaging of Mechanotransduction in Endothelial Cells; 1. Introduction; 2. Atherosclerosis, EC Wound Healing, and Mechanotransduction.
  table of contents: 3. Signaling Molecules Involved in Mechanosensing and Mechanotransduction4. The Effect of Subcellular Structure on Mechanotransduction; 5. Focal Adhesion and FAK; 6. Tools to Monitor Signal Transduction in Live Cells; 6.1. FPs, FRET, and fluorescence lifetime imaging microscopy; 6.2. Quantitative image-based analysis for live cells; 6.3. The FRAP analysis and finite-element-based diffusion analysis; 6.4. Automatic tracking of moving cells and subcellular features; 7. Conclusion; References; Part Two: Focal Adhesions as Sensors; Chapter Three: Focal Adhesions Function as a Mechanosensor.
  table of contents: 1. Introduction: The Basic Organization of Focal Adhesions2. Mechanosensitivity of Focal Adhesions; 3. Focal Adhesions and the Effects of Environmental Parameters; 4. Focal Adhesion Signals and Cell Migration; Acknowledgments; References; Chapter Four: Mechanosensation: A Basic Cellular Process; 1. Introduction; 1.1. Historical development; 1.2. Mechanosensation/-transduction; 1.3. Effects of extracellular matrix stiffness; 1.4. Stress generated by external compression/contractility; 1.5. Stress generated by cell contractility; 1.6. Biological relevance of external and internal stress.
  table of contents: 2. Focal Adhesions2.1. Mechanotransduction/-signaling; 2.2. Focal adhesion proteins; 2.2.1. Vinculin; 2.2.2. Zyxin; 2.2.3. Talin; 2.2.4. Paxillin, Pyk2; 2.2.5. p130Cas; 2.2.6. Focal adhesion kinase; 2.3. Force transduction at focal adhesions; 2.4. Protein crosstalk; 2.5. Cell signaling pathways; 2.6. Translation of information gathered at focal adhesions; 2.7. Focal adherence junctions; 2.8. Measuring mechanotransduction/-sensation; 2.8.1. Flow chambers and cone and plate rheometers; 2.8.2. Magnetic and optical traps; 2.8.3. Atomic force microscopy and biomembrane force probe.
  note: edited by Adam J. Engler, Sanjay Kumar.
  note: 2.8.4. Cell stretcher.
  note: Includes bibliographical references at the end of each chapters and index.
  subject:
    topic: Biomechanics
  subject:
    topic: Cells
    topic: Mechanical properties
  subject:
    topic: Cellular signal transduction
  subject:
    topic: Tissue engineering
  subject:
    topic: MEDICAL
    topic: Physiology
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Human Anatomy & Physiology
  subject:
    topic: Biomechanics
  subject:
    topic: Cells
    topic: Mechanical properties
  subject:
    topic: Cellular signal transduction
  subject:
    topic: Tissue engineering
  classification: QH645.5
  classification: 571.6
  related item:
    title info:
      title: Mechanotransduction
    name:
      name part: Engler, Adam J.
    origin info:
      publisher: Burlington : Elsevier Science, ©2014
  related item:
    title info:
      title: Progress in molecular biology and translational science ; volume 126
  identifier: 9780123983275
  identifier: 0123983274
  identifier: 9780123946249
  identifier: 0123946247
  identifier: https://www.sciencedirect.com/science/bookseries/18771173/126
  record info:
    record content source: EBLCP
    record creation date: 140809
    record change date: 20180501122020.0
    record identifier: ocn886112722
    language of cataloging:
      language term: eng