rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Blood-brain barrier in drug discovery
    sub title: optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs
  title info:
    title: Optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs
  name:
    name part: Di, Li
    role:
      role term: editor.
  name:
    name part: Kerns, Edward Harvel
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2015
    copyright date: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xiv, 586 pages, 4 unnumbered pages of plates) : illustrations (some color)
  abstract: "Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"--Provided by publisher.
  table of contents: Introduction and overview / Li Di, and Edward H. Kerns -- Part 1: Pharmacokinetics of brain exposure. Pharmacokinetics of CNS penetration / Andreas Reichel -- Free drug hypothesis for CNS drug candidates / Xingrong Liu and Cuiping Chen -- Species differences and impact of disease state on BBB / Jean-Marie Nicolas -- Part 2: Mechanisms of drugs across the blood-brain barrier. Passive diffusion permeability of the BBB: examples and SAR / Scott Summerfield, Phil Jeffrey, Jasminder Sahi, and Liangfu Chen -- Efflux transport at the BBB: examples and SAR / Jerome Hochman -- Establishment of P-glycoprotein structure-transport relationships to optimize CNS exposure in drug discovery / Jerome H. Hochman, Sookhee N. Ha, and Robert P. Sheridan -- Uptake transport at the BBB: examples and SAR / Ziquiang Cheng and Qian Liu -- Transport of protein and antibody therapeutics across the blood-brain barrier / William M. Pardridge -- Part 3: Predicting and measuring brain exposure of drugs. In silico tools for assessing brain exposure / Hongming Chen, Susanne Winiwarter, and Ola Engkvist -- In vitro assays for assessing BBB permeability: vascular cells, artificial membranes, brain slice, cell uptake / Alex Avdeef, Mária A. Deli, and Winfried Neuhaus -- Human-based in vitro endothelial cell models / Hannah K. Wilson and Eric Shusta -- Methods for assessing brain binding / Li Di and Cheng Chang -- In vivo studies of brain exposure in drug discovery / Edward H. Kerns -- PBPK modelling approach for predictions of human CNS drug brain distribution / Elizabeth C.M. de Lange -- PK/PD modeling of CNS drug candidates / Johan Gabrielsson, Stephan Hjorth, and Lambertus A. Peletier -- Microdialysis to assess free drug concentration in brain / William Kielbasa and Robert E. Stratford, Jr. -- Imaging techniques for central nervous system (CNS) drug discovery / Lei Zhang and Anabella Villalobos -- Part 4: Modulating brain penetration of leads during drug discovery. Designing CNS drugs for optimal b…
  note: edited by Li Di, Edward H. Kerns.
  note: Includes bibliographical references and index.
  subject:
    topic: Blood-brain barrier
    topic: Metabolism
  subject:
    topic: Drug development
  subject:
    topic: MEDICAL
    topic: Pharmacology
  subject:
    topic: Blood-Brain Barrier
    topic: metabolism
  subject:
    topic: Central Nervous System Agents
    topic: pharmacokinetics
  subject:
    topic: Blood-Brain Barrier
    topic: drug effects
  subject:
    topic: Central Nervous System Diseases
    topic: drug therapy
  subject:
    topic: Drug Discovery
    topic: methods
  subject:
    topic: Drug-Related Side Effects and Adverse Reactions
    topic: prevention & control
  classification: RM315
  classification: 615.7/8
  classification: WL 200
  related item:
    title info:
      title: Blood-brain barrier in drug discovery
    origin info:
      publisher: Hoboken, New Jersey : John Wiley & Sons Inc., [2015]
    identifier: (DLC) 2014040935
    identifier: (OCoLC)889736023
  identifier: 9781118788493
  identifier: 1118788494
  identifier: 9781118788547
  identifier: 1118788540
  identifier: 9781118788523
  identifier: 1118788524
  identifier: 9781322572406
  identifier: 1322572402
  identifier: 9781118788356
  identifier: 1118788354
  identifier: 2014041569
  identifier: 688522 MIL
  identifier: https://doi.org/10.1002/9781118788523
  record info:
    record content source: DLC
    record creation date: 141017
    record change date: 20170124071141.9
    record identifier: ocn893389733
    language of cataloging:
      language term: eng