rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Matrix metalloproteinase biology
  name:
    name part: Sagi, Irit
    role:
      role term: editor.
  name:
    name part: Gaffney, Jean
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Discussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, Matrix Metalloproteinase Biologyis a collection of chapters written by leaders in the field of MMPs. The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases. The text first provides an overview of MMPs, focusing on the history, the development and failures of small molecule inhibitors in clinical trials, and work with TIMPS, the endogenous inhibitors of MMPs. These introductory chapters establish the foundation for later discussion of the recent progress on the design of different types of inhibitors, including novel antibody based therapeutics. The following section emphasizes research using novel methods to further the study of the MMPs. The third and final section focuses on in vivo research, particularly with respect to cancer models, degradation of the extracellular matrix, and MMP involvement in other disease states. Written and edited by leaders in the field, Matrix Metalloproteinase Biology addresses the rapidly growth in MMP research, and will be an invaluable resource to advanced students and researchers studying cell and molecular biology.
  table of contents: Matrix metalloproteinases : from structure to function / Maciej J. Stawikowski and Gregg B. Fields -- Dynamics and mechanisms of substrate recognition by matrix metalloproteinases / Ivan E. Collier and Gregory Goldberg -- Matrix metalloproteinases : structure and dynamics in substrates recognition and processing / Marco Fragai, Claudio Luchinat -- Metzincin modulators : beyond the active site / Dmitriy Minond -- Therapeutics targeting matrix metalloproteinases / Jillian Cathcard, Ashleigh Pulkoski-Gross, Stanley Zucker, and Jian Cao -- Matrix metalloproteinases : modification of extracellular matrix-medicated signaling / Howard C. Crawford and M. Sharon Stack -- Meprin and Adam metalloproteinases : two sides of the same coin? / Christopher Becker-Pauly and Stefan Rose-John -- Metalloproteinases in innate immunity and disease / Antoine Dufour and Christopher Overall -- MMPS : from genomics to degradomics / Barbara Grünwald, Pascal Schlage, Achim Krüger, and Ulrich auf dem Keller -- Biology and clinical significance of MMPS / Di Jia, Roopali Roy, and Marsha A. Moses.
  note: edited by Irit Sagi and Jean P. Gaffney.
  note: Includes bibliographical references and index.
  subject:
    topic: Metalloproteinases
  subject:
    topic: Extracellular matrix proteins
  subject:
    topic: Matrix Metalloproteinases
  subject:
    topic: SCIENCE / Life Sciences / Biochemistry
  subject:
    topic: Matrix Metalloproteinases
  classification: QP552.M47
  classification: 572/.696
  classification: QU 136
  related item:
    title info:
      title: Matrix metalloproteinase biology
    origin info:
      publisher: Hoboken, NJ : John Wiley & Sons Inc., [2015]
    identifier: (DLC) 2015000037
  identifier: 9781118772386 (ePub)
  identifier: 1118772385 (ePub)
  identifier: 9781118772294 (Adobe PDF)
  identifier: 1118772296 (Adobe PDF)
  identifier: 9781118772324 (cloth)
  identifier: 9781118772287
  identifier: 1118772288
  identifier: 2015001033
  identifier: https://doi.org/10.1002/9781118772287
  record info:
    record content source: DLC
    record creation date: 150112
    record change date: 20170124071633.9
    record identifier: ocn900159220
    language of cataloging:
      language term: eng