rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Successful drug discovery
  name:
    name part: Fischer, János
    role:
      role term: editor.
  name:
    name part: Rotella, David P.
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: gw
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds:small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting andlong-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of thedrug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
  table of contents: Part I: General Aspects. Serendipitous Target-Based Drug Discoveries / János Fischer, David P Rotella -- Drug Discoveries and Molecular Mechanism of Action / David C Swinney -- Part II: Drug Class. Insulin Analogs -- Improving the Therapy of Diabetes / John M Beals -- Part III: Case Histories. The Discovery of Stendra (Avanafil) for the Treatment of Erectile Dysfunction / Koichiro Yamada, Toshiaki Sakamoto, Kenji Omori, Kohei Kikkawa -- Dapagliflozin, A Selective SGLT2 Inhibitor for Treatment of Diabetes / William N Washburn -- Elvitegravir, A New HIV-1 Integrase Inhibitor for Antiretroviral Therapy / Hisashi Shinkai -- Discovery of Linagliptin for the Treatment of Type 2 Diabetes Mellitus / Matthias Eckhardt, Thomas Klein, Herbert Nar, Sandra Thiemann -- The Discovery of Alimta (Pemetrexed) / Edward C Taylor -- Perampanel: A Novel, Noncompetitive AMPA Receptor Antagonist for the Treatment of Epilepsy / Shigeki Hibi -- Discovery and Development of Telaprevir (Incivek): A Protease Inhibitor to Treat Hepatitis C Infection / Bhisetti G Rao, Mark Murcko, Mark J Tebbe, Ann D Kwong -- Antibody-Drug Conjugates: Design and Development of Trastuzumab Emtansine (T-DM1) / Sandhya Girish, Gail D Lewis Phillips, Fredric S Jacobson, Jagath R Junutula, Ellie Guardino.
  note: edited by János Fischer and David P. Rotella.
  note: Includes bibliographical references and index.
  subject:
    topic: Drugs
    topic: Design
  subject:
    topic: Pharmaceutical chemistry
  subject:
    topic: Medical
  subject:
    topic: MEDICAL
    topic: Pharmacology
  subject:
    topic: Drugs
    topic: Design
  subject:
    topic: Pharmaceutical chemistry
  classification: RS420
  classification: 615.1/9
  related item:
    identifier: (OCoLC)903897512
  identifier: 9783527678433
  identifier: 3527678433
  identifier: 1322949557
  identifier: 9781322949550
  identifier: 9783527678457
  identifier: 352767845X
  identifier: EB00596207 Recorded Books
  identifier: 726237 MIL
  identifier: https://doi.org/10.1002/9783527678433
  record info:
    record content source: DG1
    record creation date: 150223
    record change date: 20170124070752.7
    record identifier: ocn903897512
    language of cataloging:
      language term: eng