http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (x, 262 pages) : illustrations.
Genetics, Genomics and Fish Phenomics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions, with hhis volume focusing on genetics, genomics, and phenomics of fish.
Front Cover; Genetics, Genomics and Fish Phenomics; Serial Editors; Genetics, Genomics and Fish Phenomics; Copyright; Contents; CONTRIBUTORS; One -- Studying the Evolution of the Vertebrate Circadian Clock: The Power of Fish as Comparative Models ; 1. INTRODUCTION; 1.1 What Are Circadian Clocks and Why Should We Study Them?; 1.2 Why Use Fish Genetic Models to Study Clocks?; 2. HOW DO FISH CLOCKS DIRECTLY SENSE LIGHT?; 2.1 Light-Inducible Gene Expression; 2.2 Peripheral Photoreceptors; 3. HOW DO FISH (AND CLOCKS) ADAPT DURING EVOLUTION UNDER PERPETUAL DARKNESS?; 3.1 Different Cave Environments
3.2 Blind Clocks in Phreatichthys andruzzii3.3 Differences Between Surface and Cave Clocks in Astyanax; 3.4 Has the Astyanax Light-Response Altered Within Cave Strains?; 3.5 Astyanax in the Field; 3.6 Cavefish Sleep, Activity, and Metabolism; 4. OUTLOOK; ACKNOWLEDGMENTS; REFERENCES; Two -- Genomic and Transcriptomic Approaches to Study Cancer in Small Aquarium Fish Models ; 1. INTRODUCTION; 2. CANCER MODELS IN FISH; 3. GENOMIC APPROACHES; 4. TRANSCRIPTOMIC APPROACHES; 4.1 Melanoma; 4.2 Rhabdomyosarcoma; 4.3 Hepatocellular Carcinoma; 5. OUTLOOK; ACKNOWLEDGMENTS; REFERENCES
Three -- Gal4 Driver Transgenic Zebrafish: Powerful Tools to Study Developmental Biology, Organogenesis, and Neurosc ... 1. INTRODUCTION; 2. TOL2-MEDIATED TRANSGENESIS IN ZEBRAFISH; 3. THE GAL4-UAS SYSTEM IN ZEBRAFISH; 3.1 The Emergence of the Gal4-UAS System in Zebrafish; 3.2 Tol2-Mediated Gal4 Gene Trapping and Enhancer Trapping; 3.3 Additional Improvements in the Gal4-UAS System; 4. APPLICATIONS OF GAL4 DRIVERS; 4.1 Inhibition of Neuronal Activities via Targeted Expression of a Neurotoxin Gene; 4.2 Visualization of Neuronal Activities by Calcium Imaging
4.3 Genetic Dissection of the Motor System4.4 The Architecture of Cerebellar Neural Circuits; 4.5 Proliferation and Differentiation of the Lateral Line System; 4.6 Spatiotemporal Functions of Notch Signaling; 5. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Four -- Whole-Organism Cellular Pathology: A Systems Approach to Phenomics ; 1. INTRODUCTION; 1.1 Phenotype; 1.2 Phenomics and Phenome Projects; 1.3 Phenotype Omission Error; 1.4 Stereomicroscopy; 1.5 Molecular Imaging Versus Pan-Cellular Phenotyping; 1.6 Why Histological Phenotyping?; 2. LESSONS FROM LIGHT MICROSCOPY
2.1 Early Tissue Phenotyping2.2 Histological Phenotyping in Medicine; 2.3 Histological Phenotyping in Zebrafish; 2.3.1 Method and Tool Development for Zebrafish Histology; 2.3.2 Lessons From Creating a Web-Based Histology Atlas; 2.3.3 Lessons From Phenotyping Zebrafish Using Histology; 2.3.3.1 From a Histological Mutagenesis Screen; 2.3.3.2 The Potential Utility of Volumetric Data; 2.3.3.3 From a Histological Screen of Existing Mutants Found by Stereomicroscopy; 3. WHOLE-ORGANISM CELLULAR PATHOLOGY AS A SYSTEMS APPROACH TO PHENOMICS; 3.1 The Need for Whole-Organism Cellular Pathology
System requirements: Adobe Acrobat Reader.
Includes bibliographical references and index.
SCIENCE / Life Sciences / Zoology / Ichthyology & Herpetology
[San Diego, California] : Academic Press : Elsevier Inc., 2016