rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Coronaviruses
  name:
    name part: Ziebuhr, John
    role:
      role term: editor.
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: mau
    place:
      place term: Cambridge, MA
    publisher: Academic Press
    date issued: Ã2016
    date issued: 2016
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  table of contents: Front Cover; Coronaviruses; Copyright; In Memoriam; Contents; Contributors; Preface; Chapter One: Supramolecular Architecture of the Coronavirus Particle; 1. Introduction; 2. Virion Structure and Durability; 3. Viral Proteins in Assembly and Fusion; 3.1. Membrane Protein; 3.2. Nucleoprotein; 3.3. Envelope Protein; 3.4. Spike Protein; 4. Evolution of the Structural Proteins; References; Chapter Two: Coronavirus Spike Protein and Tropism Changes; 1. Introduction; 2. Structure of the Coronavirus S Protein; 2.1. Structure of the S1 Subunit; 2.2. Structure of the S2 Subunit.
  table of contents: 3. Spike-Receptor Interactions3.1. Different Domains Within S1 May Act as RBD; 3.2. CoV Protein Receptor Preference; 4. S Protein Proteolytic Cleavage and Conformational Changes; 5. Tropism Changes Associated with S Protein Mutations; 5.1. S1 Receptor Interactions Determining Tropism; 5.1.1. S1 NTR Changes; 5.1.2. S1 CTR Changes; 5.2. Changes in Proteolytic Cleavage Site and Other S2 Mutations Associated with Altered Tropism; 5.2.1. Changes in Proteolytic Cleavage Sites; 5.2.2. Other S2 Mutations Associated with Altered Tropism; 6. Concluding Remarks; Acknowledgments; References.
  table of contents: Chapter Three: The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing1. Introduction; 2. Coronavirus nsp7-10: Small but Critical Regulatory Subunits?; 2.1. Coronavirus nsp7; 2.2. Coronavirus nsp8 and nsp7-nsp8 Complexes; 2.3. Coronavirus nsp9; 2.4. Coronavirus nsp10; 3. Coronavirus nsp12: A Multidomain RNA Polymerase; 3.1. The nsp12 RdRp Domain; 3.2. The Initiation Mechanism of the nsp12 RdRp; 3.3. Inhibitors of the nsp12 RdRp; 3.4. The nsp12 NiRAN Domain; 4. Coronavirus nsp13: A Multifunctional and Highly Conserved Helicase Subunit.
  table of contents: 4.1. The Coronavirus nsp13 SF1 Helicase (HEL1)4.2. The Helicase-Associated ZBD; 4.3. Nidovirus Helicase Structural Biology; 4.4. Functional Characterization of the Nidovirus Helicase; 4.5. The Coronavirus Helicase as Drug Target; 5. The Coronavirus Capping Machinery: nsp10-13-14-16; 5.1. The nsp13 RNA 5' Triphosphatase; 5.2. The Elusive RNA GTase; 5.3. The nsp14 N7-Methyl Transferase; 5.4. The nsp16 2'-O-Methyl Transferase; 6. Coronavirus nsp14 ExoN: Key to a Unique Mismatch Repair Mechanism That Promotes Fidelity; 7. Coronavirus nsp15: A Remarkable Endoribonuclease with Elusive Functions.
  table of contents: 8. Summary and Future PerspectivesAcknowledgments; References; Chapter Four: Coronavirus cis-Acting RNA Elements; 1. Introduction; 2. Coronavirus Genome Replication and Transcription; 3. Coronavirus cis-Acting RNA Elements; 3.1. 5-Terminal cis-Acting RNA Elements; 3.1.1. Structural Features of Coronavirus 5'-Terminal cis-Acting Elements; 3.1.2. Functional Roles of Coronavirus 5'-Terminal cis-Acting Elements; 3.1.2.1. Stem-Loops 1 and 2; 3.1.2.2. Stem-Loop 3; 3.1.2.3. Stem-Loop 4; 3.1.2.4. Stem-Loop 5; 3.2. 3'-Terminal cis-Acting RNA Elements.
  note: edited by John Ziebuhr.
  note: Includes index.
  subject:
    topic: Coronaviruses
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Biology
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Microbiology
  subject:
    topic: Coronaviruses
  classification: QR399
  classification: 579.2/56
  related item:
    identifier: (OCoLC)950450190
  related item:
    title info:
      title: Advances in virus research ; v. 96
  identifier: 9780128051153
  identifier: 0128051159
  identifier: 9780128047361
  identifier: 0128047364
  identifier: https://www.sciencedirect.com/science/bookseries/00653527/96
  record info:
    record content source: YDX
    record creation date: 161005
    record change date: 20180501122033.0
    record identifier: ocn959951527
    language of cataloging:
      language term: eng