http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xxvii, 353 pages) : illustrations (chiefly color).
"Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides a survey of the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science to an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. Selected chapters review the latest advances in translating the new technologies to a broader range of neurodegenerative diseases, stroke, spinal cord injury, glial and retinal disease and pain than had hitherto been considered possible, with the realization that the opportunities of off-the-shelf cell therapy may fast be approaching a plausible reality"--Publisher's description.
Mechanisms and use of neural transplants for brain repair / Stephen B. Dunnett and Anders Björklund -- Reprogramming of somatic cells: iPS and iN cells / Vania Broccoli -- Brain repair from intrinsic cell sources: turning reactive glia into neurons / Olof Torper and Magdalena Götz -- Ex vivo gene therapy for the treatment of neurological disorders / Genevieve Gowing , Soshana Svendsen and Clive N. Svendsen -- Preparation, characterization and banking of clinical-grade cells for neural transplantation: scale up, fingerprinting and genomic stability of stem cell lines / Ammar Natalwala and Tilo Kunath -- Regulatory considerations for pluripotent stem cell therapies / Melissa K. Carpenter -- Strategies for bringing stem cell-derived dopamine neurons to the clinic: a European approach (STEM-PD) / Agnete Kirkeby, Malin Parmar and Roger A. Barker -- Strategies for bringing stem cell-derived dopamine neurons to the clinic: the NYSTEM trial / Lorenz Studer -- Strategies for bringing stem cell-derived dopamine neurons to the clinic: the Kyoto trial / Jun Takahashi -- From open to large-scale randomised cell transplantation trials in Huntington's disease: lessons from the multicentric intracerebral grafting in Huntington's Disease trial (MIG-HD) and previous pilot studies / Anne-Catherine Bachoud-Lévi -- Pluripotent stem cell-derived neurons for transplantation in Huntington's disease / Meng Li and Anne E. Rosser -- Advanced imaging of transplant survival, fate, differentiation, and integration / Nadja Van Camp, Elsa Diguet and Philippe Hantraye -- Rehabilitation training in neural restitution / Susanne Clinch, Monica Busse, Mate D. Döbrössy and Stephen B. Dunnett.
edited by Stephen B. Dunnett and Anders Björklund.
Includes bibliographical references and index.
Cambridge, MA : Academic Press is an imprint of Elsevier, 2017