http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Front Cover; Sterol Regulation of Ion Channels; Copyright; Contents; Contributors; Preface; Acknowledgments; Section 1: Membrane Structure and General Mechanisms of Sterol Regulation of Ion Channels; Chapter One: Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other ...; 1. Introduction; 2. Experimental Validation of the CARC Motif; 3. Coexistence of CARC and CRAC Sequences Within the Same TM Domain; 4. Reliability of the CARC and CRAC Algorithms; 5. Cholesterol and Its Key Role in Liquid-Ordered Lipid Domains
6. Evolutionary Conservation of Sterol-Recognition MotifsAcknowledgments; References; Chapter Two: Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response; 1. Introduction; 2. Physical Properties of Membrane Bilayer: Sterol Analysis; 2.1. 3D Sterol Structure of Cholesterol Chiral Analogues; 2.2. Position Within the Bilayer; 2.3. Lipid Order and Packing; 3. Differential Effects of Sterols on the Ion Channel Function: Prevalence of Stereospecific Effects; 3.1. Stereospecific Effects of Cholesterol on Ion Channels
3.1.1. Inwardly Rectifying K+ (Kir) Channels3.1.2. Large-Conductance Ca2+-Sensitive Voltage-Gated K+ Channels (BK); 3.1.3. Transient Receptor Potential Vanilloid 1 (TRPV1) Channels; 3.1.4. GABAA Receptors; 3.2. Nonstereospecific Effects of Cholesterol on Ion Channels; 3.2.1. Nicotinic Acetylcholine Receptor (nAChR); 3.2.2. Volume-Regulated Anion Channels (VRACs); 4. Evidence for Direct Binding and Sterol Competition for the Binding Sites: Kir Channels; 4.1. Challenges of the Approach; 4.2. Cholesterol Binding to KirBac1.1 Channels Is Not Stereospecific
5. Computational Analysis of the Stereospecificity of Cholesterol Binding to Ion Channels6. Conclusions and Future Directions; Acknowledgments; References; Section 2: Structural Determinants of Cholesterol-Ion Channels Interactions; Chapter Three: Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites; 1. Biology and Chemistry of Cholesterol and Bile Acids; 1.1. Cholesterol in Physiology and Disease; 1.2. Bile Acids in Physiology and Disease; 1.3. Connections in the Chemistry and Metabolism of Cholesterol and Bile Acids
1.4. Evidence for Direct Interactions Between Cholesterol and Ion Channel Proteins1.5. Evidence for Direct Interactions Between Bile Acids and Ion Channel Proteins; 2. Modulation of BK Channels by Cholesterol or Bile Acids; 2.1. Voltage- and Ca2+-Gated, Large Conductance K+ (BK) Channels; 2.2. Cholesterol and BK Channel-Mediated Currents; 2.3. Mechanisms Underlying Cholesterol Modulation of BK Channel Activity; 2.3.1. Mechanisms Driven by Changes in the Physicochemical Properties of the Lipid Bilayer; 2.3.2. Direct Cholesterol-BK Protein Interactions
SCIENCE / Life Sciences / Anatomy & Physiology