rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Current topics in membranes
    sub title: sterol regulation of ion channels
  name:
    name part: Levitan, Irena
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: mau
    date issued: 2017
    copyright date: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (308 pages).
  table of contents: Front Cover; Sterol Regulation of Ion Channels; Copyright; Contents; Contributors; Preface; Acknowledgments; Section 1: Membrane Structure and General Mechanisms of Sterol Regulation of Ion Channels; Chapter One: Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other ...; 1. Introduction; 2. Experimental Validation of the CARC Motif; 3. Coexistence of CARC and CRAC Sequences Within the Same TM Domain; 4. Reliability of the CARC and CRAC Algorithms; 5. Cholesterol and Its Key Role in Liquid-Ordered Lipid Domains
  table of contents: 6. Evolutionary Conservation of Sterol-Recognition MotifsAcknowledgments; References; Chapter Two: Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response; 1. Introduction; 2. Physical Properties of Membrane Bilayer: Sterol Analysis; 2.1. 3D Sterol Structure of Cholesterol Chiral Analogues; 2.2. Position Within the Bilayer; 2.3. Lipid Order and Packing; 3. Differential Effects of Sterols on the Ion Channel Function: Prevalence of Stereospecific Effects; 3.1. Stereospecific Effects of Cholesterol on Ion Channels
  table of contents: 3.1.1. Inwardly Rectifying K+ (Kir) Channels3.1.2. Large-Conductance Ca2+-Sensitive Voltage-Gated K+ Channels (BK); 3.1.3. Transient Receptor Potential Vanilloid 1 (TRPV1) Channels; 3.1.4. GABAA Receptors; 3.2. Nonstereospecific Effects of Cholesterol on Ion Channels; 3.2.1. Nicotinic Acetylcholine Receptor (nAChR); 3.2.2. Volume-Regulated Anion Channels (VRACs); 4. Evidence for Direct Binding and Sterol Competition for the Binding Sites: Kir Channels; 4.1. Challenges of the Approach; 4.2. Cholesterol Binding to KirBac1.1 Channels Is Not Stereospecific
  table of contents: 5. Computational Analysis of the Stereospecificity of Cholesterol Binding to Ion Channels6. Conclusions and Future Directions; Acknowledgments; References; Section 2: Structural Determinants of Cholesterol-Ion Channels Interactions; Chapter Three: Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites; 1. Biology and Chemistry of Cholesterol and Bile Acids; 1.1. Cholesterol in Physiology and Disease; 1.2. Bile Acids in Physiology and Disease; 1.3. Connections in the Chemistry and Metabolism of Cholesterol and Bile Acids
  table of contents: 1.4. Evidence for Direct Interactions Between Cholesterol and Ion Channel Proteins1.5. Evidence for Direct Interactions Between Bile Acids and Ion Channel Proteins; 2. Modulation of BK Channels by Cholesterol or Bile Acids; 2.1. Voltage- and Ca2+-Gated, Large Conductance K+ (BK) Channels; 2.2. Cholesterol and BK Channel-Mediated Currents; 2.3. Mechanisms Underlying Cholesterol Modulation of BK Channel Activity; 2.3.1. Mechanisms Driven by Changes in the Physicochemical Properties of the Lipid Bilayer; 2.3.2. Direct Cholesterol-BK Protein Interactions
  note: edited by Irena Levitan.
  subject:
    topic: Ion channels
  subject:
    topic: Sterols
  subject:
    topic: SCIENCE / Life Sciences / Anatomy & Physiology
  subject:
    topic: Ion channels
  subject:
    topic: Sterols
  classification: QH603.I54
  classification: 571.64
  related item:
    identifier: (OCoLC)985078868
  related item:
    title info:
      title: Current topics in membranes ; v. 80
  identifier: 0128096209
  identifier: 9780128096208
  identifier: 0128093889
  identifier: 9780128093887
  identifier: https://www.sciencedirect.com/science/bookseries/10635823/80
  record info:
    record content source: IDEBK
    record creation date: 170923
    record change date: 20180501122037.0
    record identifier: on1004968422
    language of cataloging:
      language term: eng