http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xiv, 302 pages) : illustrations (some color), charts.
""Front Cover""; ""Selenium and Selenoproteins in Cancer""; ""Copyright""; ""Contents""; ""Contributors""; ""Preface""; ""Chapter One: The Epidemiology of Selenium and Human Cancer""; ""1. Introduction""; ""2. Selenium and Cancer: Scope of Research""; ""3. Observational Studies""; ""4. Randomized Controlled Trials""; ""5. The Nutritional Prevention of Cancer Trial""; ""6. The Selenium and Vitamin E Cancer Prevention Trial""; ""7. The Other Trials""; ""8. A Natural Experiment on Selenium and Cancer""; ""9. Selenium in Cancer Therapy""; ""10. Conclusion""; ""Acknowledgments""; ""References""
""Chapter Two: Selenoproteins in Tumorigenesis and Cancer Progression""""1. Introduction""; ""2. Selenoprotein Production""; ""3. Investigating Selenoproteins Through Sec tRNA Mutations""; ""4. Role of Specific Selenoproteins in Tumorigenesis""; ""4.1. Selenoprotein P""; ""4.2. Glutathione Peroxidases""; ""4.3. Thioredoxin Reductases""; ""4.4. Selenoprotein F""; ""5. Considerations and Conclusions""; ""Acknowledgments""; ""References""; ""Chapter Three: Selenoproteins and Metastasis""; ""1. Introduction""; ""2. Metastasis""; ""2.1. Local Invasion""; ""2.2. Intravasation""
""2.3. Survival in Vasculature, Extravasation, and Formation of Micrometastases""""3. Dietary Selenium and Selenium Supplementation""; ""4. Thioredoxin Reductases and Redox Tone""; ""5. GPX and ROS Regulation""; ""6. Selenoproteins Involved in ER Stress and Calcium Flux""; ""7. Other Potential Roles for Selenoproteins in Metastasis""; ""8. Conclusions""; ""Acknowledgments""; ""References""; ""Chapter Four: Selenium-Dependent Glutathione Peroxidases During Tumor Development""; ""1. Introduction""; ""2. Expression Profile of Se-Dependent GPxes in Different Types of Tumors""
""3. Hydroperoxides and Redox Signaling During Cancer Development""""4. Impact of Individual GPxes on Tumor Development""; ""4.1. GPx1""; ""4.1.1. Cell Death""; ""4.1.2. Redox Signaling""; ""4.1.3. Metabolism""; ""4.2. GPx2""; ""4.2.1. Cell Death""; ""4.2.2. Redox Signaling""; ""4.3. GPx3""; ""4.3.1. Cell Death""; ""4.3.2. Redox Signaling""; ""4.4. GPx4""; ""4.4.1. Cell Death""; ""4.4.2. Redox Signaling""; ""5. Conclusions""; ""Acknowledgment""; ""References""; ""Chapter Five: Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy""; ""1. Introduction""
""1.1. The Thioredoxin System""""1.2. Thioredoxin Reductase 1""; ""2. TrxR1 as an Important Enzyme in Cancer""; ""3. Conclusions""; ""Acknowledgments""; ""References""; ""Chapter Six: The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium""; ""1. Tumor Microenvironment: Interplay With Immune Cells and Pathways of Inflammation""; ""2. Selenium-Dependent Effects on Cancer Stem Cells in Leukemia""; ""3. Interaction of LSCs With Immune Cells Mediated by CyPGs""; ""4. Targeting LSC Metabolism With Selenium""; ""5. Summary""; ""Acknowledgments""
edited by Kenneth D. Tew, Francesco Galli.