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Nanomedicine in Central Nervous System Injury and Repair
1 online resource (xv, 165 pages : illustrations).
Nanomedicine in Central Nervous System Injury and Repair (IRN), Volume 137, the latest release in the International Review of Neurobiology series presents comprehensive chapters that cover a broad range of topics, including, but not limited to, how Diabetes exacerbates methamphetamine induced blood-brain barrier breakdown, edema formation, oxidative stress and myelin damage, and how Focal blast brain injury induces rapid edema formation, blood-brain barrier breakdown and intensive cellular damage. In addition, the Neuroprotective effects of a multimodal drug cerebrolysin are explored, as is how Nanowired cerebrolysin potentiates neuroprotective effects of histamine H3 receptor inverse agonist and antagonist with partial H4 agonist in Alzheimer's Disease. This series reviews current knowledge and understanding on how to repair the damaged spinal cord and brain with nanomedicine, detailing new therapeutic advances and providing a starting point for researchers and practitioners entering the field.
""Front Cover""; ""Nanomedicine in Central Nervous System Injury and Repair""; ""Copyright""; ""Contents""; ""Contributors""; ""Preface""; ""References""; ""Acknowledgments""; ""Chapter One: Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders""; ""1. Introduction""; ""2. Physical Delivery""; ""3. Nonphysical Methods""; ""3.1. Systemic Delivery""; ""3.2. In Vitro Targeting""; ""3.3. In Vivo Proteins, Fusion Proteins, and Modified Enzymes""; ""3.4. Nanoparticle-Based Delivery""; ""4. Conclusion""; ""References""
""Chapter Two: Impact of Inflammation on the Blood-Neural Barrier and Blood-Nerve Interface: From Review to Therapeutic Preview""""1. Introduction""; ""2. Blood-Nerve Interface""; ""3. Mast Cells and the BBB""; ""4. Immune Cell Interactions Amplify Neuroinflammation""; ""5. Neuroinflammation and Aging""; ""6. Mast Cells and Glia as Therapeutic Targets""; ""7. Conclusion and Perspectives""; ""Acknowledgments""; ""Conflict of Interest""; ""References""; ""Chapter Three: Intravenous Administration of Functionalized Magnetic Iron Oxide Nanoparticles Does Not Induce CNS Injury ...""
""1. Introduction""""1.1. Magnetic Iron Oxide Nanoparticles""; ""1.2. Polymer-Coated Iron Oxide Nanoparticles""; ""1.3. Superparamagnetic Iron Oxide Nanoparticles""; ""2. Experimental Procedures""; ""3. SCI Model""; ""4. Nanoparticle Administration""; ""5. Treatment With Cerebrolysin""; ""5.1. Blood-Spinal Cord Barrier/BBB Permeability""; ""5.2. Edema Formation""; ""5.3. Morphological Changes in the Cord""; ""5.4. Experimental Observations""; ""5.4.1. Iron Oxide Nanoparticles Effect on BSCB/BBB Permeability""; ""5.4.2. Morphological Changes Inside the Cord""
""6. Effects of Cerebrolysin on BBB/BSCB Permeability""""6.1. Effects of Cerebrolysin on Neuronal and Glial Cell Damage""; ""6.2. Probable Mechanisms of IOMNP-Induced Neurotoxicity""; ""6.3. Cerebrolysin-Induced Neuroprotection""; ""7. Conclusion and Future Perspectives""; ""Acknowledgments""; ""References""; ""Chapter Four: Histaminergic Receptors Modulate Spinal Cord Injury-Induced Neuronal Nitric Oxide Synthase Upregulation and ...""; ""1. Introduction""; ""2. Histamine in the Spinal Cord""; ""3. Histamine and Nitric Oxide Interaction""
""4. Histamine and the Spinal Cord Microcirculation""""5. Histamine and the BSCB Permeability""; ""6. Histamine and Spinal Cord Edema""; ""7. Nanowired Drug Delivery Enhances Neuroprotection""; ""8. Our Investigations on Histamine-Receptor Modulation and nNOS Expression in SCI""; ""8.1. Animals""; ""8.2. Spinal Cord Injury""; ""8.3. Drug Treatments""; ""8.4. TiO2-Nanowired Delivery of Cimetidine and Ranitidine""; ""8.5. Parameters Measured""; ""8.6. BSCB Permeability""; ""8.7. Spinal Cord Edema""; ""8.8. Spinal Cord Blood Flow""; ""8.9. Morphological Analyses""
International review of neurobiology ; v. 137