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Forkhead FOXO transcription factors in development and disease
Forkhead FOXO Transcription Factors in Development and Disease, Volume 127, the latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease. Each chapter is contributed by a leading expert in the field, with specific sections covering Exceptional Longevity: Insights from Hydra to Humans, FOXO in neural cells and diseases of the nervous system, maintaining the equilibrium for better or for worse, and The Role of FoxOs in Bone Health and Disease, amongst other topics. This compilation provides a unique, up-to-date view of this enigmatic, highly evolutionary conserved family of transcription factors with a diverse array of functions in aging and longevity, cancer, and metabolism.
Front Cover; Forkhead FOXO Transcription Factors in Development and Disease; Copyright; Contents; Contributors; Preface; Chapter One: DAF-16: FOXO in the Context of C. elegans; 1. Introduction; 2. Identification of daf-16; 2.1. Genetic; 2.2. Molecular; 3. Isoforms; 4. Direct Phosphorylation; 4.1. AKT-1/AKT-2/SGK-1; 4.2. Jun Kinase; 4.3. AMP Kinase; 5. Cofactors/Interacting Proteins; 5.1. NHL-1; 5.2. SWI/SNF; 5.3. 14-3-3 Proteins; 5.4. SMK-1; 5.5. STK4/CST-1; 6. Additional Inputs; 6.1. Heat Shock Factor-1; 7. Target Genes; 8. Conclusion; Acknowledgments; References
Chapter Two: Stem Cells Seen Through the FOXO Lens: An Evolving Paradigm1. FOXO and Stem Cells; 2. FOXO in Embryonic Stem Cells and Development; 3. FOXO in Adult Tissue-Specific Stem Cells; 4. FOXO in Hematopoietic Stem Cells; 4.1. FOXO3, Reactive Oxygen Species, and Mitochondria in HSC; 4.2. FOXO and Autophagy in HSC; 4.3. FOXO and DNA Damage Response in HSC; 4.4. FOXO, mTOR, and Myeloproliferation; 4.5. FOXO and Leukemic Stem Cells; 4.6. FOXO, HSC Longevity, and the Role of Sirtuins and miRNAs; 5. FOXO and Neural Stem Cells; 6. FOXO3 and Muscle Stem Cells; 7. Concluding Remarks
AcknowledgmentsReferences; Chapter Three: FOXOs Maintaining the Equilibrium for Better or for Worse; 1. Introduction: FOXO Regulation Getting up to Par; 2. The PI3K/PKB(AKT)/FOXO Signaling Pathway and Cancer; 3. FOXOs and the Hallmarks of Cancer; 3.1. FOXOs and the Hallmarks: Sustaining Proliferative Signaling; 3.2. FOXOs and the Hallmarks: Resisting Cell Death; 3.3. FOXOs and the Hallmarks: Enabling Replicative Immortality; 3.4. FOXOs and the Hallmarks: Inducing Angiogenesis; 3.5. FOXOs and the Hallmarks: Activating Invasion and Metastasis
3.6. FOXOs Genuine or ""Bona Fide"" Tumor Suppressor3.7. FOXOs: Tumor Suppressors or Promoters?; 4. FOXOs as Rheostats in Homeostasis; 4.1. Redox; 4.2. DNA Damage Response; 4.3. Protein Homeostasis; 5. FOXOs and Resistance to Therapy; 5.1. Quiescence as a Mechanism of Resistance; 5.2. The Role of Feedback Signaling in Acquiring Resistance; 5.3. Cross Talk With Other Pathways; 6. Conclusion; References; Further Reading; Chapter Four: FOXO in Neural Cells and Diseases of the Nervous System; 1. Introduction; 2. Neural Development and Stem Cell Maintenance
3. Neuronal Survival and Stress Responses4. Phenotypic Consequences of FOXO Loss; 5. Neurodegenerative Disease; 6. Future Directions; References; Further Reading; Chapter Five: Regulation of Hepatic Glucose Metabolism by FoxO Proteins, an Integrated Approach; 1. Overview; 2. Early Studies and Early Insights; 3. Regulation of FoxO Function by Insulin/PI3K/Akt Signaling and Deacetylases; 4. Effects on Gluconeogenic Gene Expression; 5. Effects on Glycolysis and Glucose Utilization; 6. Effects of Fatty Acid Oxidation on Glycolysis and Gluconeogenesis
Current topics in developmental biology ; v. 127