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Chemical and Biochemical Approaches for the Study of Anesthetic Function
"Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data. We have selected the primary experts to write about each approachThis provides one-stop shopping for all the means of addressing this complex questionAnesthesia is enormously important as almost everybody receives it at some point"--
Part A: Chapter One: Physical Accuracy Leads to Biological Relevance: Best Practices For Simulating Ligand-Gated Ion Channels Interacting with General Anesthetics / Sruthi Murlidaran, Grace Brannigan -- Chapter Two: Computational Approaches to Studying Voltage-Gated Ion Channel Modulation by General Anesthetics / Eleonora Gianti, Vincenzo Carnevale -- Chapter Three: Molecular Mechanics Parameterization of Anesthetic Molecules / Thomas T. Joseph, Jérôme Hénin -- Chapter Four: Insights Into Receptor-Based Anesthetic Pharmacophores and Anesthetic-Protein Interactions / Victoria S. Fahrenbach, Edward J. Bertaccini -- Chapter Five: Understanding Anesthetic Mechanisms: Analysis of the Complex Kinetics of Ligand-Gated Ion Channels / Robert S. Cantor -- Chapter Six: General Genetic Strategies / Louise M. Steele, Philip G. Morgan -- Chapter Seven: Approaches to Anesthetic Mechanisms: The C. elegans Model / Louise M. Steele, Margaret M. Sedensky -- Chapter Eight: Using Drosophila to Understand General Anesthesia: From Synapses to Behavior / Shanker Karunanithi, Michael Troup, Bruno van Swinderen -- Chapter Nine: High-Throughput Screening to Identify Anesthetic Ligands Using Xenopus laevis Tadpoles / Kellie A. Woll, Roderic G. Eckenhoff -- Chapter Ten: Zebrafish: A Pharmacogenetic Model for Anesthesia / Victoria Bedell, Elena Buglo, Daniel Marcato, Christian Pylatiuk, Ralf Mikut, Johannes Stegmaier, Will Scudder, Maxwell Wray, Stephan Zuchner, Uwe Strahle, Ravindra Peravali, and Julia E. Dallman -- Chapter Eleven: The Mouse as a Model Organism for Assessing Anesthetic Sensitivity / Andrzej Z. Wasilczuk, Kaitlyn L. Maier, Max B. Kelz -- Chapter Twelve: Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry / Kellie A. Woll, William P. Dailey, Roderic G. Eckenhoff -- Chapter Thirteen: Xenon-Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR / Benjamin W. Roose, Serge D. Zemerov, Ivan J. Dmochowski -- Chapter Fourteen: Methods for Defining the Neuroprotective Properties of Xenon / Richie Robel, Peter Caroccio, Mervyn Maze -- Chapter Fifteen: Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration / Andrew McKinstry-Wu, Charles W. Carspecken, Alex Proekt, Max B. Kelz -- Chapter Sixteen: Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms / Paul Hoerbelt, Boris D. Heifets -- Chapter Seventeen: Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics / Elaine Yang, Lianteng Zhi, Qiansheng Liang, Manuel Covarrubias -- Chapter Eighteen: Combining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels / Stuart A. Forman -- Chapter Nineteen: HCN and K2P Channels in Anesthetic Mechanisms Research / Paul M. Riegelhaupt, Gareth R. Tibbs, Peter A. Goldstein.
Part B: Chapter One: Structural Analysis of Anesthetics in Complex with Soluble Proteins / Patrick J. Loll -- Chapter Two: X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels / Qiang Chen, Yan Xu, Pei Tang -- Chapter Three: Solution NMR Studies of Anesthetic Interactions with Ion Channels / Vasyl Bondarenko, Marta Wells, Yan Xu, Pei Tang -- Chapter Four: Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion Channels / J. Kent Blasie -- Chapter Five: Fluorescent Anesthetics / Daniel J. Emerson, Ivan J. Dmochowski -- Chapter Six: Investigation of Anesthetic-Protein Interactions by a Thermodynamic Approach / Hasan Babazada, Renyu Liu -- Chapter Seven: Electron Spin Resonance (EPR) in Drosophila and General Anesthesia / Luca Turin, Efthimios M.C. Skoulakis -- Chapter Eight: Giant Plasma Membrane Vesicles: An Experimental Tool for Probing the Effects of Drugs and Other Conditions on Membrane Domain Stability / Zoe Gerstle, Rohan Desai, Sarah L. Veatch -- Chapter Nine: Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs / Megan McGrath, Douglas E. Raines -- Chapter Ten: Optoanesthesia: Use of Anesthetic Photolabels In Vivo / Andrew R. McKinstry-Wu, Max B. Kelz -- Chapter Eleven: Optogenetics and Chemogenetics / Ksenia Vlasov, Christa J. Van Dort, Ken Solt -- Chapter Twelve: Genetic Reporters of Neuronal Activity: c-Fos and G-CaMP6 / Andrew E. Hudson -- Chapter Thirteen: Genomics and Proteomic Techniques / Jonathan Z. Pan -- Chapter Fourteen: Neurochemistry of Anesthetic States / Ralph Lydic, Helen A. Baghdoyan, Amanda L. May -- Chapter Fifteen: Brief Introduction to Electroencephalography / Alex Proekt -- Chapter Sixteen: Using Positron Emission Tomography in Revealing the Mystery of General Anesthesia: Study Design Challenges and Opportunities / Harry Scheinin, Emilee C. Alkire, Annalotta Scheinin, Michael T. Alkire, Oskari Kantonen, and Jaakko Långsjö -- Chapter Seventeen: Brain Imaging Using Hyperpolarized 129Xe Magnetic Resonance Imaging / Simrun Chahal, Braedan R.J. Prete, Alanna Wade, Francis T. Hane, and Mitchell S. Albert.
edited by Roderic G. Eckenhoff, Ivan J. Dmochowski.
Chemical and Biochemical Approaches for the Study of Anesthetic Function. Part A
Cambridge, MA : Academic Press, an imprint of Elsevier, 2018