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Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic regulation in schizophrenia, Progress in the epigenetics of depression, the epigenetics of circadian rhythms in imprinted neurodevelopmental disorders, DNA methylation mediating substance abuse, mechanisms and therapeutic opportunities, DNA methylation in animals model of psychosis, Epigenetics of early life stress, Epigenetic drugs for mood disorders, and more. Accessible to students and researchers alike, with content that appeals to a variety of readersWritten by leading authorities in their respective fields of molecular biology.
Cover; Title Page; Copyright page; Contents; Contributors; Preface; Chapter One -- Epigenetic Landscapes of the Adversity-Exposed Brain; Abstract; 1 Introduction; 1.1 Early Adversity, Epigenetics, and Psychiatric Disorder; 1.2 DNA Methylation; 2 Specificity of experience-induced methylation changes; 2.1 Tissue Specificity; 2.2 Cell-type Specificity; 3 Beyond methylation; 3.1 DNA Hydroxymethylation; 3.2 Early Adversity and the Hydroxymethylome; 4 Sex differences; 4.1 Animal Models; 4.2 Humans; 5 Methylation across the lifespan; 6 What we do not know and how we get there
6.1 Tissue- and Cell-type Specificity6.2 Hydroxymethylation and Non-CG Methylation; 6.3 Sex Differences; 6.4 Lifespan Methylation; 7 Concluding remarks; Acknowledgements; References; Chapter Two -- Chromosomal Conformations and Epigenomic Regulation in Schizophrenia; Abstract; 1 Introduction to the epigenomics of schizophrenia; 2 Regulation of chromosomal conformations in neurodevelopment; 2.1 Building Blocks of the 3D Genome; 2.2 Chromosomal Scaffolding Protein Mutations and Neuropsychiatric Disease; 3 Loop disruptions potentially involved in schizophrenia: early findings
3.1 Promoter-Enhancer Loops and Transcriptional Regulation3.2 Evidence for Loop Disruption in Brains of Subjects With Schizophrenia; 4 (EPI)Genomic editing of loop-bound regulatory sequences in the preclinical model; 5 Future directions; Acknowledgment; References; Chapter Three -- Progress in Epigenetics of Depression; Abstract; 1 Introduction; 2 Overview of epigenetic mechanisms; 2.1 DNA Methylation; 2.2 Chromatin Modifications; 2.3 Noncoding RNAs; 2.4 3D Chromatin Structure; 3 Methods for studying epigenetics and depression; 4 DNA methylation in depression
5 Histone modifications in depression5.1 Histone Acetylation; 5.2 Histone Methylation; 6 Chromatin remodeling in depression; 7 Regulation of the 3D genome in depression; 8 Noncoding RNAs in depression; 9 Conclusions; Acknowledgments; References; Chapter Four -- Epigenetics of Circadian Rhythms in Imprinted Neurodevelopmental Disorders; Abstract; 1 DNA methylation; 2 Long, noncoding RNAs; 3 Neurodevelopmental disorders involving imprinting and circadian rhythms; 3.1 Prader-Willi and Angelman Syndromes; 3.2 Kagami-Ogata and Temple Syndromes; 4 Mechanisms of imprinting in neurodevelopment
5 Circadian rhythms and imprinting in neurodevelopment6 Chronotherapeutics; Acknowledgements; References; Chapter Five -- The Role of DNA Methylation in Drug Addiction: Implications for Diagnostic and Therapeutics; Abstract; 1 Introduction; 2 Animal models of drug addiction; 3 DNA methylation in animal models of drug addiction; 4 Alterations in DNA methylation associated with drug addiction in human; 5 DNA methylation as a biomarker; 6 Future directions; Acknowledgments; References; Chapter Six -- DNA Methylation in Animal Models of Psychosis; Abstract
Includes bibliographical references and index.
London ; San Diego, CA : Academic Press, [2018]
Progress in molecular biology and translational science ; v. 157