Nuclear receptors : a practical approach /

The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Άλλοι συγγραφείς: Picard, Didier
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: New York : Oxford University Press, 1999.
Σειρά:Practical approach series ; 207.
Θέματα:
Διαθέσιμο Online:http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=98496
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245 0 0 |a Nuclear receptors :  |b a practical approach /  |c edited by Didier Picard. 
260 |a New York :  |b Oxford University Press,  |c 1999. 
300 |a 1 online resource (xviii, 285 pages) :  |b illustrations (some color). 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
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490 1 |a Practical approach series ;  |v 207 
504 |a Includes bibliographical references and index. 
588 0 |a Print version record. 
520 |a The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is guided through the functional characterization of coactivators using microinjection. The next section covers receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a model system for looking at receptor function. The final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new. 
505 0 0 |g Machine generated contents note:  |g 1.  |t Evolutionary biology of the nuclear receptor superfamily /  |r M. Robinson /  |r H. Escriva /  |r V. Laudet --  |g 2.  |t Initial characterization of new orphan receptors /  |r R. Sladek /  |r V. Giguere --  |g 3.  |t Adopting orphans: finding ligands /  |r W. Wahli /  |r S. Kersten --  |g 4.  |t Kinetic analysis of nuclear receptor interactions /  |r L.P. Freedman /  |r B.J. Cheskis --  |g 5.  |t Functional characterization of co-activators using mammalian cell microinjection /  |r T.-M. Mullen /  |r M.G. Rosenfeld /  |r [and others] /  |r D.W. Rose --  |g 6.  |t Analysis of steroid/nuclear receptor phosphorylation /  |r N.L. Weigel /  |r B.G. Rowan --  |g 7.  |t Ligand- and cofactor-regulated transcription with chromatin templates /  |r W.L. Kraus /  |r J.T. Kadonaga --  |g 8.  |t Hormone-resistance syndromes /  |r M. Gurnell /  |r V.K.K. Chatterjee --  |g 9.  |t In vitro assembly of steroid receptor -- Hsp90 complexes /  |r D.F. Smith --  |g 10.  |t Yeast as a system for the study of nuclear receptor function /  |r M.J. Garabedian /  |r J.A. Iniguez-Lluhi /  |r A. Kralli --  |g 11.  |t Regulation of heterologous proteins by fusion to a hormone binding domain /  |r D. Picard. 
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650 0 |a Steroid hormones  |x Receptors. 
650 0 |a Nuclear receptors (Biochemistry) 
650 0 |a Transcription factors. 
650 7 |a SOCIAL SCIENCE  |x Anthropology  |x Physical.  |2 bisacsh 
650 0 7 |a Steroid hormones  |x Receptors.  |2 cct 
650 0 7 |a Nuclear receptors (Biochemistry)  |2 cct 
650 0 7 |a Transcription factors.  |2 cct 
650 0 7 |a Receptors, Cytoplasmic and Nuclear.  |2 cct 
650 0 7 |a Receptors, Steroid.  |2 cct 
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650 1 2 |a Receptors, Cytoplasmic and Nuclear. 
650 1 2 |a Transcription Factors. 
650 2 2 |a Receptors, Steroid. 
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700 1 |a Picard, Didier. 
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