Molecular diversity in drug design /

• Άλλοι συγγραφείς: Dean, P. M. (Philip Michael), 1944-, Lewis, Richard A.
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht, the Netherlands ; Boston : Kluwer Academic Publishers, �1999.
• Θέματα: Drugs > Design.; Pharmaceutical chemistry.; Molecular biology.; Drugs > Structure-activity relationships.; Combinatorial chemistry.; Drug Design.; Chemistry, Pharmaceutical.; Molecular Biology.; Structure-Activity Relationship.; MEDICAL > Drug Guides.; MEDICAL > Pharmacology.; MEDICAL > Pharmacy.; MEDICAL > Nursing > Pharmacology.; Electronic books.

This book focuses on the theoretical problems associated with molecular diversity as it is being applied in the pharmaceutical industry. Therefore, this book deals with algorithms that are involved in understanding chemical space and selection of diverse sets of structures. The algorithms also deal...

Πίνακας περιεχομένων:

• Issues in molecular diversity and the role of ligand binding sites / James Smith, Philip M. Dean and Richard A. Lewis
• Molecular diversity in drug design : application to high-speed synthesis and high-throughput screening / Christopher G. Newton
• Background theory of molecular diversity / Valerie J. Gillet
• Absolute vs relative similarity and diversity / Jonathan S. Mason
• Diversity in very large libraries / Lutz Weber and Michael Almstetter
• Subset-selection methods for chemical databases / P. Willett
• Molecular diversity in site-focused libraries / Diana C. Roe
• Managing combinatorial chemistry information / Keith Davies and Catherine White
• Design of small libraries for lead exploration / Per M. Andersson [and others]
• The design of small- and medium-sized focused combinatorial libraries / Richard A. Lewis.